SPECT with I-123 labeled F(ab')/sub 2/ fragments from monoclonal anti-CEA antibodies in colon carcinoma
Eleven patients with colorectal carcinoma were studied, 4 with primary, 7 with recurrent (1) or metastatic lesions. After injection of 1,5mg of F(ab')/sub 2/ of monoclonal anti-CEA antibodied No 35 (n=9) or 202 (n=2) labeled with I-123 (p,5n) (3-4mCi) whole body distribution was measured on anterior and posterior views at 1,6,24,48 h. SPECT was performed with a dual head device at 6,24,48 h. F(ab')/sub 2/ No 202 showed relatively high bone marrow uptake and high urinary activity (74% of injected activity in 3 days), but low liver activity (x-bar 14% of whole body activity at 24 h ). With F(ab')/sub 2/ No 35 bone marrow activity was lower, mean relative liver uptake 17% and mean urinary activity 24%. In 2 surgical specimens tumor to normal tissue ratios were measured at day 5 post injection and found to be 6,8,15,9 for one, 3,5,7,2 for the other in comparison with mucosa, serosa, fat and blood respectively. All 5 localized carcinoma were detected by ECT, the best images being obtained at 24 h. On the 6 h scans 4 patients with liver metastases showed cold lesions which became positive on the 24 h ECT in 2 of them whereas the 2 others remained doubtful. 2 patients with liver involvement showed no uptake. In 1 patient under therapy 2 small lung metastases were not detected. 2/2 bone metastases showed tracer uptake 1 of them was previously unknown. High quality images can be obtained with this method already at 24 h but the detection of metastases especially in the liver is sometimes difficult.
- Research Organization:
- Ludwig Inst. for Cancer Research, Div. of Nucl. Medicine and Inst. of Biochemistry, Lausanne
- OSTI ID:
- 6590592
- Report Number(s):
- CONF-840619-; TRN: 87-018934
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CARCINOMAS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
LARGE INTESTINE
RADIOPHARMACEUTICALS
TISSUE DISTRIBUTION
UPTAKE
ANTIBODIES
BONE MARROW
CARCINOEMBRYONIC ANTIGEN
IMAGES
INTRAVENOUS INJECTION
LABELLING
LIVER
MONOCLONAL ANTIBODIES
NEOPLASMS
PATIENTS
RADIONUCLIDE KINETICS
ANIMAL TISSUES
ANTIGENS
BODY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DRUGS
EMISSION COMPUTED TOMOGRAPHY
GASTROINTESTINAL TRACT
GLANDS
HEMATOPOIETIC SYSTEM
INJECTION
INTAKE
INTESTINES
LABELLED COMPOUNDS
ORGANS
TISSUES
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550501 - Metabolism- Tracer Techniques