Biodistribution of I-123-iodo-amphetamine in man
Biodistribution and in vivo kinetics of iodo-amphetamine were studied in 18 patients (13 CVC, 3 metastases, 2 seizures). After 10 min of complete rest 5 mCi of N-isopropyl-p-(123I)-iodo-amphetamine(p,5n) were injected and 5, 15, 30, 45, 60, 90, 120 min blood samples taken. Whole body tracer distribution was studied with a dual head camera 30-60 and 90-120 min post-injection, at 24h in 3, at 48h in 2 patients. 3 days urinary elimination was measured in 2 patients. Brain, lung, liver, thyroid and bladder counts of anterior and posterior views were averaged and expressed as percent of WB activity. Brain ECT was performed 60 min p.i. in all, after 2h in 2 patients. Plasma activity decreased first with a fast, than with a slower component (mean Ti/2:5 and 60min respectively), than it became stable or increased slightly. 30-60min p.i. the brain concentrated an average of 5.6% of WB activity, the lungs 30.7%, the liver 19.2% and the thyroid 1%. Brain and thyroid activity did not significantly change during the second interval (6.3 and 1.1% respectively), lung activity decreased (24.7%), liver (22.7%) and bladder activity (1 to 2.3%) increased. 3 days urinary elimination was 6.3 and 7.9% of the injected dose respectively. In contrast with the findings in the primate no eye activity could be detected even at 24 and 48h. Intracerebral tracer distribution was similar on the 1 and 2h ECT. These data confirm the stability of brain activity observed in the animal between 30 and 120min after injection, but without showing any eye uptake of the tracer. Brain ECT with I-123-iodo-amphetamine may be performed during this interval under stable conditions in what concerns the absolute uptake as well as intracerebral distribution of the tracer.
- Research Organization:
- Centre Hospitalier Universitaire Vaudois, Lausanne
- OSTI ID:
- 6844857
- Report Number(s):
- CONF-840619-
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
AMPHETAMINES
ANALEPTICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLADDER
BLOOD
BODY
BODY FLUIDS
BRAIN
CAMERAS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
DIAGNOSIS
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
EXTERNAL IRRADIATION
GLANDS
HOURS LIVING RADIOISOTOPES
IN VIVO
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
IRRADIATION
ISOTOPE APPLICATIONS
ISOTOPES
LIVER
LUNGS
MATERIALS
METASTASES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
QUANTITY RATIO
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPIRATORY SYSTEM
STABILITY
SYMPATHOMIMETICS
THYROID
TISSUE DISTRIBUTION
TRACER TECHNIQUES
UPTAKE
URINARY TRACT
WHOLE-BODY IRRADIATION