(Inborn anemias of mice): Terminal progress report
Mutations located at 11 different chromosomal locations in the mouse all affecting hemopoiesis have been studied. These include: Hertwig's anemia (an), W-anemias (W, W/sup v/, W/sup 17J/ to W/sup 41J/), Steel anemias (Sl, Sl/sup d/, etc.), Normoblastic anemia (nb), Jaundiced (ja), Spherocytic anemias (sph, sph/sup ha/), sph/sup 2J/, sph/sup 2BC/, Flexed-tail anemia (f), Microcytic anemia (mk), Sex-linked anemia (Sla), Alpha thallasemia (Hba/sup th/), and a hypochromic anemia associated with low transferrin levels (hpx). Our findings indicate that the erythroid defect in W-anemias stem from an intrinsic defect in the erythroid progenitor cells, and that all other erythroid hemostatic mechanisms are fully functional. Hertwig's anemia (an) is affected in a similar fashion. However, in the case of Steel anemias, the erythroid progenitors are repressed, but when transplanted to appropriate recipients were found to be fully functional. 70 refs., 4 tabs.
- Research Organization:
- Jackson Lab., Bar Harbor, ME (USA)
- DOE Contract Number:
- AC02-76EV03264
- OSTI ID:
- 6590085
- Report Number(s):
- DOE/EV/03264-1; ON: DE87009259
- Country of Publication:
- United States
- Language:
- English
Similar Records
Inborn anemias in mice: (Annual report, 1983-1984)
Inborn anemias in mice: (Annual report, 1981-1982)
Related Subjects
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59 BASIC BIOLOGICAL SCIENCES
ANEMIAS
ANIMAL CELLS
ANIMALS
BIOLOGICAL MODELS
BLOOD FORMATION
DISEASES
ERYTHROPOIESIS
GENE REGULATION
GENETIC MAPPING
HEMIC DISEASES
HEREDITARY DISEASES
MAMMALS
MAPPING
MICE
MUTANTS
RODENTS
SOMATIC CELLS
STEM CELLS
SYMPTOMS
VERTEBRATES