Generalized formulation of dual radiation action

Journal Article · Fri Sep 01 04:00:00 EDT 1978 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574835· OSTI ID:6589328

Kellerer, A M; Rossi, H H

Dual radiation action is a process in which cellular lesions are produced as a result of the interaction of pairs of sublesions that are molecular alterations produced by ionizing radiation. Previous formulations of this process have employed a number of simplifying assumptions that limit the accuracy and the range of application of theoretical analysis. The formulation presented here removes some of these restrictions by introducing three functions that describe the geometry of the sensitive material in the cell, the geometry of the pattern of energy deposition, and the interaction probability of sublesions as a function of their separation. The relation derived is similar to that obtained previously, in that lesion production is found to depend on two terms that are proportional to the first and the second power of the absorbed dose. However, the coefficients of these terms are now derived on the basis of a more realistic treatment.

• Research Organization: Univ., Wuerzburg, Ger.
• OSTI ID: 6589328
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 75:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CONSTITUENTS
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
INJURIES
MATHEMATICAL MODELS
MOLECULAR STRUCTURE
MORPHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATION INJURIES
RADIOINDUCTION
SPATIAL DISTRIBUTION
ULTRASTRUCTURAL CHANGES