Biophysical studies with spatially correlated ions. IV. Analysis of cell survival data for diatomic deuterium

Journal Article · Mon Sep 01 04:00:00 EDT 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575333· OSTI ID:7057678

Kellerer, A M ^[1]; Lam, Y M.P.; Rossi, H H

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1. Wuerzburg Univ., Germany

An analysis is given of previously reported results of experiments in which cells have been irradiated with pairs of ions of variable mean separation. These studies were motivated by the theory of dual radiation action and specifically by the postulate that the lesions responsible for cell impairment by ionizing radiation are formed by the combination of pairs of sublesions that are molecular alterations produced by individual energy transfers in the cell nucleus. It is concluded that the observations are consistent with dual radiation action, and the most striking finding is that there appears to be a bimodal distribution of interaction distances with maxima at less than 0.1 ..mu..m and more than 1 ..mu..m. Single tracks cause primarily the lesions produced in short-range interactions but they also contribute, at least in late S phase, a relatively small proportion of the long-range interactions which are principally due to a two-track mechanism. The experiments suggest that the radiation-sensitive components of the cell are arranged in a highly nonuniform pattern which may take the form of floccules having diameters of less than 100 nm.

• DOE Contract Number: AS02-78EV04733
• OSTI ID: 7057678
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 83:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CONSTITUENTS
CELL CYCLE
CELL NUCLEI
CHARGED PARTICLES
DATA
DEUTERIUM
DEUTERONS
ENERGY TRANSFER
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
HAMSTERS
HELIUM 3
HELIUM ISOTOPES
HYDROGEN ISOTOPES
INFORMATION
INJURIES
IONIZING RADIATIONS
ISOTOPES
LET
LIGHT NUCLEI
MAMMALS
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RODENTS
SPATIAL DEPENDENCE
STABLE ISOTOPES
SURVIVAL CURVES
VERTEBRATES