(/sup 3/H) clonidine binding to rat hippocampal membranes
Alpha adrenergic receptor subtypes in rat hippocampal membranes were studied, using (/sup 3/H) clonidine as the radioactive ligand. On the basis of competitive binding studies, using the selective antagonist-prazosin, WB-4101, and yohimbine, (/sup 3/H) clonidine appeared to bind to a population of presynaptic sites that are pharmacologically similar to receptors previously classified as alpha 2. A computerized model that linearized and produced the best possible fit to the experimental data points indicated that (/sup 3/H) clonidine binds to a single population of receptors possessing equal affinity for the ligand. Binding data also indicated that rat hippo-campus contains significantly fewer (/sup 3/H)clonidine binding sites than rat cortex.
- Research Organization:
- Department of Biology, North Carolina Central University Durham, NC
- OSTI ID:
- 6586532
- Journal Information:
- Neurochem. Res.; (United States), Journal Name: Neurochem. Res.; (United States) Vol. 7:2; ISSN NERED
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ADRENALINE
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
DRUGS
HIPPOCAMPUS
HORMONES
ISOTOPE APPLICATIONS
LIGANDS
MAMMALS
MEMBRANES
NERVOUS SYSTEM
NEUROREGULATORS
ORGANS
RATS
RECEPTORS
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
TRACER TECHNIQUES
VERTEBRATES