Exogenous pigment in Peyer's patches
Journal Article
·
· Hum. Pathol.; (United States)
Dark brown granular pigment was found consistently in macrophages in the deep aspect of adult Peyer's patches. Tissue sections from intestinal resections of 35 patients with a variety of pathologic diagnoses and of seven postmortem cases with no evidence of gastrointestinal disease were examined for the presence of this pigment. It was found in all patients over the age of 6 years (34 cases) but was not found in any children below that age (eight cases). Scanning electron microscopy with secondary and backscattered electron imaging and x-ray energy spectroscopy were performed on routine histologic sections. The pigmented macrophages contained aluminum and silicon, diffusely present throughout the cytoplasm, and numerous discrete foci of titanium. Pigment containing these same elements has also been found around dilated submucosal lymphatics, in mesenteric lymph nodes, and in some transmural inflammatory aggregates of Crohn's disease. The pigment probably is derived from the diet and actively taken up by Peyer's patches, which are able to incorporate inert particulate matter.
- Research Organization:
- St. Bartholomew's Hospital, West Smithfield, London, England
- OSTI ID:
- 6586266
- Journal Information:
- Hum. Pathol.; (United States), Journal Name: Hum. Pathol.; (United States) Vol. 1; ISSN HPCQA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ALUMINIUM
ANIMAL CELLS
BIOLOGICAL ACCUMULATION
CHEMICAL COMPOSITION
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM DISEASES
DISEASES
DISTRIBUTION
ELECTRON MICROSCOPY
ELEMENTS
MACROPHAGES
METALS
MICROSCOPY
PATHOGENESIS
PATIENTS
PHAGOCYTES
PIGMENTS
SCANNING ELECTRON MICROSCOPY
SEMIMETALS
SILICON
SOMATIC CELLS
SPECTROSCOPY
TISSUE DISTRIBUTION
TITANIUM
TRANSITION ELEMENTS
UPTAKE
X-RAY SPECTROSCOPY
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ALUMINIUM
ANIMAL CELLS
BIOLOGICAL ACCUMULATION
CHEMICAL COMPOSITION
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM DISEASES
DISEASES
DISTRIBUTION
ELECTRON MICROSCOPY
ELEMENTS
MACROPHAGES
METALS
MICROSCOPY
PATHOGENESIS
PATIENTS
PHAGOCYTES
PIGMENTS
SCANNING ELECTRON MICROSCOPY
SEMIMETALS
SILICON
SOMATIC CELLS
SPECTROSCOPY
TISSUE DISTRIBUTION
TITANIUM
TRANSITION ELEMENTS
UPTAKE
X-RAY SPECTROSCOPY