Prolonged survival of lung allografts in nonidentical beagles by treatment with lethal total-body irradiation, autologous bone marrow transplantation, and methotrexate. [Gamma radiation]

Journal Article · Fri Sep 01 00:00:00 EDT 1978 · Transplantation; (United States)

OSTI ID:6585628

Blumenstock, D A; Cannon, F D

Techniques are described for /sup 60/Co irradiation of beagles and transplantation of bone marrow and lungs. Eight pairs of animals that were treated with lethal irradiation, marrow transplantation, and methotrexate were alive after 68 to 245 days. Biopsies revealed normal transplanted lungs. Results indicated that the combination of treatments was significant since survival was markedly increased over various control series receiving lesser degrees of therapy or none. (HLW)

• Research Organization: Columbia Univ., Coopertown, NY
• OSTI ID: 6585628
• Journal Information: Transplantation; (United States), Vol. 26:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE MARROW
BIOLOGICAL EFFECTS
TRANSPLANTS
LUNGS
METHOTREXATE
BIOLOGICAL RADIATION EFFECTS
BEAGLES
GAMMA RADIATION
SURVIVAL TIME
ANIMALS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
BODY
DOGS
DRUGS
ELECTROMAGNETIC RADIATION
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
MAMMALS
ORGANS
RADIATION EFFECTS
RADIATIONS
RESPIRATORY SYSTEM
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals