Ozone-induced adaptive and reactive cellular changes in respiratory bronchioles of bonnet monkeys

Journal Article · Thu Jan 01 04:00:00 EST 1987 · Exp. Lung Res.; (United States)

DOI:https://doi.org/10.3109/01902148709068814· OSTI ID:6583610

Moffatt, R K; Hyde, D M; Plopper, C G; Tyler, W S; Putney, L F

To characterize the response of respiratory bronchioles (RBs) to chronic high ambient levels of ozone, bonnet monkeys were exposed for 90 days to 0, 0.4, or 0.64 ppm ozone (UV photometric standard; 3 monkeys/exposure). Morphologic changes in respiratory bronchiolar epithelium and interstitium were evaluated quantitatively at both the light and transmission electron microscopic levels. Significant changes in respiratory bronchioles following exposure included: a thicker wall and a narrower lumen, a thicker epithelial compartment and a much thicker interstitial compartment, shifts in epithelial cell populations with many more nonciliated bronchiolar epithelial cells and fewer squamous type I epithelial cells, larger nonciliated bronchiolar epithelial cells with a larger complement of cellular organelles associated with protein synthesis, greater amounts of both interstitial fibers and amorphous ground substance, greater numbers of interstitial smooth muscle cells per epithelial basal lamina surface area, and greater volumes of interstitial smooth muscle, macrophages, mast cells, and neutrophils per epithelial basal lamina surface area. These observations imply that chronic ozone exposure causes a concentration-dependent reactive peribronchiolar inflammatory response and an adaptive response consisting of hypertrophy and hyperplasia of the nonciliated bronchiolar cell.

• Research Organization: California Primate Research Center, Davis
• OSTI ID: 6583610
• Journal Information: Exp. Lung Res.; (United States), Journal Name: Exp. Lung Res.; (United States) Vol. 1; ISSN EXLRD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
BRONCHI
CHRONIC EXPOSURE
CONNECTIVE TISSUE
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
EPITHELIUM
MACROPHAGES
MAMMALS
MAST CELLS
MONKEYS
MUSCLES
OZONE
PATHOLOGICAL CHANGES
PHAGOCYTES
PRIMATES
RESPIRATION
RESPIRATORY SYSTEM
SOMATIC CELLS
TISSUES
TOXICITY
VERTEBRATES