Chronic bronchiolitis in nonhuman primates after prolonged ozone exposure

Journal Article · Thu Jan 01 04:00:00 EST 1981 · Am. J. Pathol.; (United States)

OSTI ID:5657035

Eustis, S L; Schwartz, L W; Kosch, P C; Dungworth, D L

Bonnet monkeys (Macaca radiata) were exposed to 0.0, 0.5, or 0.8 ppm ozone for 7, 28, or 90 consecutive days, 8 hours per day. The pulmonary response was evaluated by means of pulmonary function testing, light microscopy, scanning electron microscopy, transmission microscopy, autoradiography, and morphometry. Pulmonary function values obtained before exposure did not statistically differ from values obtained after exposure. A general trend of increased quasistatic compliance of the lung was observed in both groups of exposed monkeys. Morphologic changes were principally characterized as low-grade chronic respiratory bronchiolitis. Tritiated thymidine labeling and counts of respiratory bronchiolar epithelium demonstrated up to a 37-fold increase in labeling index at 7 days but only a sevenfold increase at 90 days. Differential cell counts demonstrated an increase in the proportion of cuboidal bronchiolar cells constituting the respiratory bronchiolar epithelium. In control monkeys, 60% of the epithelial cells were cuboidal bronchiolar cells. At 90 days of exposure, more than 90% of the respiratory bronchiolar cells were cuboidal in appearance. The cuboidal bronchiolar cell in control monkeys does not appear secretory, but membrane-bound electron-dense secretory granules are present in this cell type from exposed monkeys. Epithelial hyperplasia (increased number of cells per millimeter of airway length) persisted through 90 days of exposure at a level slightly above that present at 7 days.

• Research Organization: California Primate Research Center and Department of Pathology, School of Veterinary Medicine, University of California, Davis, California
• OSTI ID: 5657035
• Journal Information: Am. J. Pathol.; (United States), Journal Name: Am. J. Pathol.; (United States) Vol. 105:2; ISSN AJPAA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AUTORADIOGRAPHY
BIOLOGICAL EFFECTS
BODY
BRONCHITIS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTRON MICROSCOPY
INFLAMMATION
LABELLED COMPOUNDS
LUNGS
MACROPHAGES
MAMMALS
MICROSCOPY
MONKEYS
MORPHOLOGY
ORGANS
OZONE
PATHOLOGICAL CHANGES
PHAGOCYTES
PRIMATES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SCANNING ELECTRON MICROSCOPY
SOMATIC CELLS
SYMPTOMS
TRITIUM COMPOUNDS
VERTEBRATES