Interactive radiopharmaceutical facility between Yale Medical Center and Brookhaven National Laboratory. Progress report, November 1, 1980-October 31, 1981

Technical Report · Sat Oct 31 04:00:00 EST 1981

DOI:https://doi.org/10.2172/6583176· OSTI ID:6583176

Gottschalk, A

Research conducted in three principal areas is discussed and summarized. (1) Investigation of the influence of antiarrhythmic agents, such as lidocaine and procainamide, on the chemotaxis and nylon fiber adherence of indium-111-labelled human polymorphonulcear leukocytes (PMNs) in vitro revealed that at normal therapeutic levels of lidocaine and procaine, the adherence and chemotactic function of In-111-PMNs remain unaltered. Results with higher therapeutic blood levels are also discussed. (2) An improved method for labeling human platelets with In-111-oxine is outlined, and the influence of centrifugal force, oxine, ethanol, and radiation on platelet function is reported. Results indicate that normal labeling procedures induce no gross changes in platelet function. (3) The chemical preparation of radioiodinated arachidonic acid (AA) and nonradioactive acid ester of AA, and the analysis of metabolites of these compounds following myocardial ischemia were investigated in dogs. The tissue uptake of /sup 131/I-AA was compared to that of thallium-201.

• Research Organization: Yale Univ., New Haven, CT (USA). School of Medicine
• DOE Contract Number: AS02-76EV04078
• OSTI ID: 6583176
• Report Number(s): DOE/EV/04078-T1
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADHESION
ADRENAL HORMONES
AGGLOMERATION
ALCOHOLS
ANESTHETICS
ANIMALS
ARACHIDONIC ACID
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BLOOD PLASMA
BLOOD PLATELETS
BODY
BODY FLUIDS
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CENTRIFUGATION
CHEMICAL PREPARATION
CHEMICAL PROPERTIES
CHROMATOGRAPHY
COMPARATIVE EVALUATIONS
CORTICOSTEROIDS
DAYS LIVING RADIOISOTOPES
DISEASES
DISTRIBUTION
DOGS
DOSE-RESPONSE RELATIONSHIPS
DOSES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ELECTRON MICROSCOPY
ETHANOL
EVALUATION
GLUCOCORTICOIDS
HEART
HEAVY NUCLEI
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROCORTISONE
HYDROXY COMPOUNDS
IMMUNE REACTIONS
IN VITRO
INDIUM 111
INDIUM ISOTOPES
INFLAMMATION
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KETONES
LABELLED COMPOUNDS
LEUKOCYTES
MAMMALS
MATERIALS
MICROSCOPY
MINUTES LIVING RADIOISOTOPES
MONOCARBOXYLIC ACIDS
MORPHOLOGICAL CHANGES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NEUTROPHILS
NUCLEI
NYLON
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC POLYMERS
ORGANS
OXINE
PATHOLOGICAL CHANGES
PATIENTS
PETROCHEMICALS
PETROLEUM PRODUCTS
PLASTICS
POLYAMIDES
POLYMERS
PREGNANES
PROCAINE
PROSTAGLANDINS
PYRIDINES
QUINOLINES
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
RADIONUCLIDE KINETICS
SECONDS LIVING RADIOISOTOPES
SEPARATION PROCESSES
STEROID HORMONES
STEROIDS
SYMPTOMS
SYNTHESIS
THALLIUM 201
THALLIUM ISOTOPES
THIN-LAYER CHROMATOGRAPHY
TISSUE DISTRIBUTION
TRITIUM COMPOUNDS
VASCULAR DISEASES
VERTEBRATES