Interactive radiopharmaceutical facility between Yale Medical Center and Brookhaven National Laboratory. Progress report, November 1, 1980-October 31, 1981
Research conducted in three principal areas is discussed and summarized. (1) Investigation of the influence of antiarrhythmic agents, such as lidocaine and procainamide, on the chemotaxis and nylon fiber adherence of indium-111-labelled human polymorphonulcear leukocytes (PMNs) in vitro revealed that at normal therapeutic levels of lidocaine and procaine, the adherence and chemotactic function of In-111-PMNs remain unaltered. Results with higher therapeutic blood levels are also discussed. (2) An improved method for labeling human platelets with In-111-oxine is outlined, and the influence of centrifugal force, oxine, ethanol, and radiation on platelet function is reported. Results indicate that normal labeling procedures induce no gross changes in platelet function. (3) The chemical preparation of radioiodinated arachidonic acid (AA) and nonradioactive acid ester of AA, and the analysis of metabolites of these compounds following myocardial ischemia were investigated in dogs. The tissue uptake of /sup 131/I-AA was compared to that of thallium-201.
- Research Organization:
- Yale Univ., New Haven, CT (USA). School of Medicine
- DOE Contract Number:
- AS02-76EV04078
- OSTI ID:
- 6583176
- Report Number(s):
- DOE/EV/04078-T1; TRN: 81-006242
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effect of antiarrhythmic drugs on In-111-labeled leukocytes: chemotaxis and adherence to nylon wool
Interactive radiopharmaceutical facility between Yale Medical Center and Brookhaven National Laboratory. Progress report, June 1981-July 1982
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ARACHIDONIC ACID
CHEMICAL PROPERTIES
DOSE-RESPONSE RELATIONSHIPS
BLOOD PLATELETS
AGGLOMERATION
RADIONUCLIDE KINETICS
ADHESION
BIOLOGICAL EFFECTS
IMMUNE REACTIONS
INFLAMMATION
PROCAINE
BLOOD PLASMA
CENTRIFUGATION
MYOCARDIAL INFARCTION
NEUTROPHILS
BIOLOGICAL RADIATION EFFECTS
EVALUATION
ETHANOL
OXINE
RADIATION DOSES
IODINE 131
COMPARATIVE EVALUATIONS
TISSUE DISTRIBUTION
LABELLED COMPOUNDS
THIN-LAYER CHROMATOGRAPHY
MYOCARDIUM
THALLIUM 201
TRITIUM COMPOUNDS
CARBOXYLIC ACID SALTS
CHEMICAL PREPARATION
IN VITRO
INDIUM 111
HYDROCORTISONE
NYLON
PATIENTS
ELECTRON MICROSCOPY
DOGS
ISCHEMIA
PROSTAGLANDINS
ADRENAL HORMONES
ALCOHOLS
ANESTHETICS
ANIMALS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHROMATOGRAPHY
CORTICOSTEROIDS
DAYS LIVING RADIOISOTOPES
DISEASES
DISTRIBUTION
DOSES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLUCOCORTICOIDS
HEART
HEAVY NUCLEI
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KETONES
LEUKOCYTES
MAMMALS
MATERIALS
MICROSCOPY
MINUTES LIVING RADIOISOTOPES
MONOCARBOXYLIC ACIDS
MORPHOLOGICAL CHANGES
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC POLYMERS
ORGANS
PATHOLOGICAL CHANGES
PETROCHEMICALS
PETROLEUM PRODUCTS
PLASTICS
POLYAMIDES
POLYMERS
PREGNANES
PYRIDINES
QUINOLINES
RADIATION EFFECTS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
SEPARATION PROCESSES
STEROID HORMONES
STEROIDS
SYMPTOMS
SYNTHESIS
THALLIUM ISOTOPES
VASCULAR DISEASES
VERTEBRATES
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
560121 - Radiation Effects on Cells- External Source- (-1987)
560301 - Chemicals Metabolism & Toxicology- Cells- (-1987)