Remote, semiautomated production of F-18-labeled 2-deoxy-2-fluoro-D-glucose

Journal Article · Wed Apr 01 04:00:00 EST 1981 · J. Nucl. Med.; (United States)

OSTI ID:6582471

Barrio, J R; MacDonald, N S; Robinson, Jr, G D; Najafi, A; Cook, J S; Kuhl, D E

A routine production system for 2-deoxy-2-(/sup 18/F)fluoro-D-glucose (2-/sup 18/FDG) for medical use is presented. The method involves the preparation of F-18-labeled F/sub 2/ by the /sup 20/Ne(d,..cap alpha..)/sup 18/F reaction, subsequent fluorination of 3,4,6-tri-0-acetyl-D-glucal, purification, and hydrolysis of the appropriate diastereoisomer to obtain 2-/sup 18/FDG. These operations are performed using a completely remote, semiautomatic system. There have been no failures in more than 220 consecutive production runs. Currently, two preparations per day of 15 to 25 mCi of 2-/sup 18/FDG are routinely performed, with a radiochemical purity, measured by TLC, in excess of 95% and with less than 1 mR radiation exposure to the chemist. Reaction conditions, operational variables, and systems are described in detail.

• Research Organization: Univ. of California, Los Angeles
• OSTI ID: 6582471
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:4; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOHYDRATES
CHEMICAL ANALYSIS
CHEMICAL PREPARATION
CHEMICAL REACTIONS
CONTROL
DESIGN
DRUGS
EVEN-EVEN NUCLEI
FLUORINATION
FLUORINE 18
FLUORINE ISOTOPES
GLUCOSE
HALOGENATION
HAZARDS
HEALTH HAZARDS
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LIGHT NUCLEI
MEDICAL PERSONNEL
MEDICINE
MONOSACCHARIDES
NEON 20
NEON ISOTOPES
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PERFORMANCE TESTING
PERSONNEL
PRODUCTION MECHANISMS
QUANTITATIVE CHEMICAL ANALYSIS
RADIATION HAZARDS
RADIOCHEMICAL ANALYSIS
RADIOISOTOPES
RADIOLOGICAL PERSONNEL
RADIOPHARMACEUTICALS
REACTION KINETICS
REMOTE CONTROL
SACCHARIDES
STABLE ISOTOPES
SYNTHESIS
TESTING