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Treatment of prolymphocytic leukemia

Journal Article · · Cancer (Philadelphia); (United States)
;
Prolymphocytic leukemia is characterized by marked splenomegaly, distinctive cellular morphologic characteristics, and a poor clinical course. Five patients with typical PL were treated systematically with vincristine/prednisone, chlorambucil/prednisone, splenic irradiation, splenectomy, and other chemotherapy regimens. No patient responded to vincristine/prednisone. Two patients responded to chlorambucil/prednisone, and four patients had brief responses to splenic irradiation. Two patients underwent splenectomy, one of whom had a prolonged clinical remission. There were no complete remissions. No other chemotherapy combinations were of value. The median survival was 33 months. Recommendations are made to use chlorambucil/prednisone or splenic irradiation as initial treatment. Splenectomy should be considered in patients refractory to these modalities. The course of PL may be more protracted than originally reported.
Research Organization:
Department of Medicine, Cornell University Medical College, New York, New York
OSTI ID:
6581569
Journal Information:
Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 50:9; ISSN CANCA
Country of Publication:
United States
Language:
English

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Related Subjects

550600 -- Medicine
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
AMINES
ANTINEOPLASTIC DRUGS
BODY
CARBOXYLIC ACIDS
CHEMOTHERAPY
CHLORAMBUCIL
CORTICOSTEROIDS
DISEASES
DRUGS
GLUCOCORTICOIDS
HEMIC DISEASES
HORMONES
HYDROXY COMPOUNDS
KETONES
LEUKEMIA
MEDICINE
MONOCARBOXYLIC ACIDS
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PATIENTS
PREDNISONE
PREGNANES
RADIOLOGY
RADIOTHERAPY
SPLEEN
SPLENECTOMY
STEROID HORMONES
STEROIDS
SURGERY
THERAPY