Heavy ion effects on yeast: Inhibition of ribosomal RNA synthesis
- Strahlenzentrum der Justus-Liebig-Universitaet Giessen (Germany, F.R.)
Diploid wild-type yeast cells were exposed to beams of heavy ions covering a wide range of linear energy transfer (LET) (43-13,700 keV/microns). Synthesis of ribosomal RNA (rRNA) was assessed as a functional measure of damage produced by particle radiation. An exponential decrease of relative rRNA synthesis with particle fluence was demonstrated in all cases. The inactivation cross sections derived were found to increase with LET over the entire range of LET studied. The corresponding values for relative biological effectiveness were slightly less than unity. Maximum cross sections measured were close to 1 micron 2, implying that some larger structure within the yeast nucleus (e.g., the nucleolus) might represent the target for an impairment of synthetic activity by very heavy ions rather than the genes coding for rRNA. Where tested, an oxygen effect for rRNA synthesis could not be demonstrated.
- OSTI ID:
- 6579459
- Journal Information:
- Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 123:1; ISSN 0033-7587; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560130* -- Radiation Effects on Microorganisms
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCELERATORS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
CELL CONSTITUENTS
CELL NUCLEI
CHARGED PARTICLES
ENERGY TRANSFER
EUMYCOTA
FUNGI
GENES
HEAVY IONS
IONS
LINEAR ACCELERATORS
MICROORGANISMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PLANTS
RADIATION EFFECTS
RBE
RIBOSOMAL RNA
RNA
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
SYNTHESIS
YEASTS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCELERATORS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
CELL CONSTITUENTS
CELL NUCLEI
CHARGED PARTICLES
ENERGY TRANSFER
EUMYCOTA
FUNGI
GENES
HEAVY IONS
IONS
LINEAR ACCELERATORS
MICROORGANISMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PLANTS
RADIATION EFFECTS
RBE
RIBOSOMAL RNA
RNA
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
SYNTHESIS
YEASTS