Inhibitory effects of various oxygenated sterols on the differentiation and function of tumor-specific cytotoxic T lymphocytes

Journal Article · Sat May 01 04:00:00 EDT 1982 · Transplantation; (United States)

DOI:https://doi.org/10.1097/00007890-198205000-00005· OSTI ID:6578912

Spangrude, G J; Sherris, D; Daynes, R A

Irradiation of skin with ultraviolet light (UVL) is capable of causing many biological and biochemical changes in this complex organ. One early consequence is the oxidation of epidermal plasma membrane cholesterol, causing the induction of a wide variety of photoproducts. It is well recognized that some oxygenated sterols possess potent biological activity on mammalian cells by their ability to inhibit endogeneous mevalonate and cholesterol biosynthesis. In the few immunological systems that have been studied, there is general agreement that lymphocyte function is altered in the presence of certain oxygenated sterols. Insight into the biochemical basis for altered lymphocyte function is lacking, as both afferent and efferent blockades have been suggested. These studies were undertaken to determine the effect of various oxygenated sterols (representing a number of known cholesterol-derived photoproducts) on the generation (afferent) and function (efferent) of cytotoxic T lymphocytes (CTLs). Cell-mediated immune responses which result in the generation of both alloantigen-specific and syngeneic tumor-specific CTLs were evaluated. (JMT)

• Research Organization: Univ. of Utah Medical Center, Salt Lake City
• OSTI ID: 6578912
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 33:5; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARCINOGENS
CELL DIFFERENTIATION
CELL KILLING
CHEMICAL REACTIONS
CHEMISTRY
CHOLESTEROL
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
ENZYME INHIBITORS
HYDROXY COMPOUNDS
IMMUNE REACTIONS
IMMUNOSUPPRESSION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
ORGANIC COMPOUNDS
ORGANS
OXIDATION
RADIATION EFFECTS
RADIATIONS
RODENTS
SKIN
SOMATIC CELLS
STEROIDS
STEROLS
SYNTHESIS
TUMOR CELLS
ULTRAVIOLET RADIATION
VERTEBRATES