Radiation effects on the fibrinolytic system and their relation to hemorrhagic diathesis and increased endothelial permeability
This study investigates the effects of whole-body X-irradiation on the fibrinolytic system, the causes of radiation-induced changes in plasmin (fibrinolytic) activity, and the contribution of increased plasmin activity to increased capillary (endothelial) permeability and hemorrhagic diathesis. The parameters evaluated using adult, male, Rochester ex-Wistar rats were: (1) plasmin, plasminogen, and plasminogen activator levels in plasma within one month after 425, 655 or 885 rad and at 3.5, 7 and 12 months after 425 rad, by a modified caseinolytic method; (2) tissue plasminogen activator activity (TPAA) in heart, kidneys, lungs, liver, pancreas and spleen, by a fibrin plate method (885 rad); (3) vascular permeability, by a radioisotopic method (885 rad); and (4) gross hemorrhagic response, scored for severity. The dose-dependent changes in plasmin, plasminogen and plasminogen activator were multi-phasic. Combined effects of increased plasminogen and increased blood plasminogen activator caused early increase and later dramatic increase in plasmin activity (885 rad). Long-delayed radiation effects (425 rad) involved reduction in plasminogen level at 7 and 12 months. Epsilon-amino-caproic acid (0.3 gm/kg body weight) prevented the immediate and early radiation effects on these fibrinolytic components, and partially inhibited the later effects (within one month), whether administered only as a single injection before irradiation or maintained by daily water intake thereafter. 206 references, 29 figures, 34 tables.
- Research Organization:
- Rochester Univ., NY (USA). Dept. of Radiation Biology and Biophysics
- DOE Contract Number:
- AC02-76EV03490
- OSTI ID:
- 6578484
- Report Number(s):
- DOE/EV/03490-2129; ON: DE84016263
- Resource Relation:
- Other Information: Portions are illegible in microfiche products. Thesis
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
FIBRINOLYSIS
ENZYME ACTIVITY
HEXANOIC ACID
RESPONSE MODIFYING FACTORS
RATS
BIOLOGICAL RADIATION EFFECTS
BLOOD COAGULATION
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
HEMORRHAGE
WHOLE-BODY IRRADIATION
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
DATA
DECOMPOSITION
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
INFORMATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MONOCARBOXYLIC ACIDS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PROTEOLYSIS
RADIATION EFFECTS
RADIATIONS
RODENTS
SYMPTOMS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals