Effects of coal combustion and gasification process contaminants on pulmonary defense mechanisms. 3rd quarter and final progress report

Technical Report · Fri Jul 13 00:00:00 EDT 1979

OSTI ID:6573587

Lee, P

This project has involved the study of the effects of effluents from coal combustion processes on alveolar macrophage function using the rat and rabbit as the experimental animals. A number of alveolar macrophage functions are inhibited by several heavy metals (Cd, Ni, Pb) which are contained in the respirable particulates of coal combustion flyash. Lysosomal enzyme activities and lysosomal enzyme latency are inhibited but only at high metal concentrations. The same was found for phagocytosis. The oxidative responses to zymosan challenge were much more sensitive to the effects of metals with chemiluminescence being the most sensitive. 7 figures, 7 tables.

• Research Organization: West Virginia Univ., Morgantown (USA)
• DOE Contract Number: AT21-77MC08712
• OSTI ID: 6573587
• Report Number(s): DOE/MC/08712-T1; ON: DE84017597
• Country of Publication: United States
• Language: English

Related Subjects

01 COAL, LIGNITE, AND PEAT
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
BIOLOGICAL EFFECTS
FLY ASH
GASEOUS WASTES
LEAD
NICKEL
CHEMILUMINESCENCE
COAL
COAL GASIFICATION
COMBUSTION
COMBUSTION PRODUCTS
ENZYME ACTIVITY
HEALTH HAZARDS
LUNGS
LYSOSOMES
MACROPHAGES
METABOLISM
PHAGOCYTOSIS
AEROSOL WASTES
ANIMAL CELLS
ASHES
BODY
CARBONACEOUS MATERIALS
CELL CONSTITUENTS
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
ELEMENTS
ENERGY SOURCES
FOSSIL FUELS
FUELS
GASIFICATION
HAZARDS
LUMINESCENCE
MATERIALS
METALS
ORGANOIDS
ORGANS
OXIDATION
PHAGOCYTES
RESIDUES
RESPIRATORY SYSTEM
SOMATIC CELLS
THERMOCHEMICAL PROCESSES
TRANSITION ELEMENTS
WASTES
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