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Total bone uptake in management of metastatic carcinoma of the prostate

Journal Article · · J. Urol.; (United States)
OSTI ID:6571406
; ; ; ; ;
The status of patients with skeletal metastases from prostatic carcinoma was determined from a quantitative uptake and retention measurement of the bone scanning radiopharmaceutical /sup 99m/technetium-methylene diphosphonate. Whole body counts were performed 5 minutes and 24 hours after intravenous administration of /sup 99m/technetium-methylene diphosphonate, and were expressed as the percentage uptake by the skeleton at 24 hours. Skeletal uptake determinations were done in 29 patients with prostatic cancer (17 with osseous metastases) who were evaluated at 3 to 6-month intervals. Group 1 consisted of patients who responded to therapy and achieved remission, group 2 included patients with relapse or progressive disease, group 3 consisted of those with metastases who were in remission for longer than 6 months and group 4 included those without evidence of any bony metastases. The baseline mean +/- standard deviation 24-hour skeletal uptake values were 46.1 +/- 12.0 per cent in group 1, 34.3 +/- 13.9 per cent in group 2, 27.0 +/- 5.9 per cent in group 3 and 28.9 +/- 5.5 per cent in group 4. At 3 to 6 months the values in group 1 (responders) decreased by 18 per cent, while those in group 2 (relapse or progression) increased by 19 per cent and those in group 3 (remission) increased by 1.5 per cent. The quantitative 24-hour skeletal uptake test was performed easily, reproducible and at least as useful as concurrent chemical blood tests and subjective bone scan interpretations.
Research Organization:
Massachusetts General Hospital, Boston
OSTI ID:
6571406
Journal Information:
J. Urol.; (United States), Journal Name: J. Urol.; (United States) Vol. 3; ISSN JOURA
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560161* -- Radionuclide Effects
Kinetics
& Toxicology-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID PHOSPHATASE
ALKALINE PHOSPHATASE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARCINOMAS
COUNTING TECHNIQUES
DISEASES
ENZYMES
ESTERASES
GLANDS
HOURS LIVING RADIOISOTOPES
HYDROLASES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MALE GENITALS
MEDICINE
METASTASES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
PHOSPHATASES
PROSTATE
RADIOISOTOPES
RADIOLOGY
RADIONUCLIDE KINETICS
RADIOTHERAPY
SKELETON
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
UPTAKE
WHOLE-BODY COUNTING
YEARS LIVING RADIOISOTOPES