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Carcinoma of the thyroid with a mixed medullary and follicular pattern: morphologic, immunohistochemical, and clinical laboratory studies

Journal Article · · Cancer (Philadelphia); (United States)
; ; ;

We recently encountered an unusual carcinoma of the thyroid gland with a predominantly medullary pattern admixed with areas of follicular differentiation. Both patterns prevailed at the primary site and in bilateral cervical lymph node metastases. The tumor cells were stained for calcitonin by indirect immunofluorescence technique and were found to contain dense-core granules by electron microscopy. Calcitonin was demonstrated in tumor homogenates by radioimmunoassay and was elevated in the serum. Immunofluorescence staining also revealed thyroglobulin in the neoplastic cells. Moreover, following total thyroidectomy, the cervical node metastases concentrated radioactive iodine (/sup 131/I), and serum thyroglobulin was increased at one stage of the disease when measured by radioimmunoassay. These findings are discussed in the light of the dual embryonic derivation of the thyroid gland.

Research Organization:
Department of Pathology, University of California School of Medicine, San Francisco
OSTI ID:
6569649
Journal Information:
Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 50:7; ISSN CANCA
Country of Publication:
United States
Language:
English

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Related Subjects

550201 -- Biochemistry-- Tracer Techniques
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARCINOMAS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
DISEASES
ENDOCRINE GLANDS
GLANDS
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LYMPH NODES
LYMPHATIC SYSTEM
METASTASES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGY
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPES
THYROID
TRACER TECHNIQUES
TUMOR CELLS
USES