Radioiodide uptake and turnover in a pseudo-medullary thyroid carcinoma
A mass in a woman's neck, with no sequestration by Tc-99m imaging, was accompanied by an elevated serum calcitonin on one occasion. Light microscopy of a biopsy was consistent with medullary thyroid carcinoma. Electron microscopy showed secretory granules similar to those found in normal C-cells and in medullary carcinoma of the thyroid. The neck mass (and pulmonary and hepatic metastases likely from the principal mass) concentrated radioiodide (I-131). Subsequent immunoperoxidase examination of the tissues showed them to contain thyroglobulin but not calcitonin. The tumor was thus likely of follicular-cell origin. Reports of radioiodide uptake in medullary thyroid carcinoma may be correct, but each case will have to be re-examined with attention to tissue markers such as thyroglobulin and calcitonin. These markers might more correctly classify the origin of the tumor. The possibilities of cell interconversion and of dual origin are also discussed. Whole-body turnover of radioiodide was quantified as well as that in the pulmonary lesions. Rapid removal of radioactivity was present, suggesting that agents reducing iodide turnover might have therapeutic value in these cases. At five days after radioiodide administration, a biopsy specimen showed that the tumor-to-blood ratio (per gram) was greater than 1.
- Research Organization:
- Univ. of Connecticut Health Center, Farmington
- OSTI ID:
- 6516441
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:11; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Carcinoma of the thyroid with a mixed medullary and follicular pattern: morphologic, immunohistochemical, and clinical laboratory studies
Radioiodide imaging of pertechnetate ''hot'' solitary thyroid nodules
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL COMPOUNDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BODY
CALCITONIN
CARCINOMAS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON MICROSCOPY
ENDOCRINE GLANDS
GLANDS
GLOBULINS
HALIDES
HALOGEN COMPOUNDS
HORMONES
HOURS LIVING RADIOISOTOPES
IMMUNOLOGY
INORGANIC PHOSPHORS
INTERMEDIATE MASS NUCLEI
IODIDES
IODINE 131
IODINE COMPOUNDS
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MICROSCOPY
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PEPTIDE HORMONES
PEPTIDES
PERTECHNETATES
PHOSPHORS
POLYPEPTIDES
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SODIUM COMPOUNDS
SODIUM IODIDES
TECHNETIUM 99
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
THYROGLOBULIN
THYROID
TRANSITION ELEMENT COMPOUNDS
TRANSMISSION ELECTRON MICROSCOPY
YEARS LIVING RADIOISOTOPES