Derivations of relative biological effectiveness for the high-let radiations produced during boron neutron capture irradiations of the 9L rat gliosarcoma in vitro and in vivo

Journal Article · Wed Dec 01 04:00:00 EST 1993 · International Journal of Radiation Oncology, Biology and Physics; (United States)

DOI:https://doi.org/10.1016/0360-3016(93)90533-2· OSTI ID:6568829

Coderre, J A; Makar, M S; Micca, P L; Nawrocky, M M; Liu, H B; Joel, D D; Slatkin, D N ^[1]; Amols, H I ^[2]

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1. Brookhaven National Lab., Upton, NY (United States)
2. Columbia Univ., New York, NY (United States)

The purpose of this study was to independently determine RBE values for all of the boron neutron capture therapy dose components. Clonogenic cell survival data were obtained for 9L rat gliosarcoma cells irradiated in the Brookhaven Medical Research Reactor thermal neutron beam both in vitro and as an intracerebral tumor. These data were analyzed using the linear quadratic model for cell survival to derive measured RBE values for all beam components and for a number of different boron compounds. In the absence of boron, the combined effects of the protons from the nitrogen capture, [sup 14]N(n,p)[sup 14]C, and the fast neutron scatter, [sup 1]H(n,n[prime])p, reactions generated RBEs of 3.7 in vitro and 3.2 in an in vivo/in vitro excision assay, compared to 250 kVp X rays using an end point of 1% cell survival. Apparent RBEs for the [sup 10]B(n,[alpha])[sup 7]Li reaction products were calculated from cell survival data following reactor irradiations in the presence of the amino acid p-boronophenylalanine, the sulfhydryl dodecaborate monomer or dimer, or boric acid. Apparent RBEs for the [sup 10]B(n,[alpha])[sup 7]Li reaction ranged from 1.2 to 9.8 depending on which boron compound was used. RBEs from the in vitro studies were consistently higher than from the in vivo/in vitro studies. Under any conditions, the apparent RBE for the [sup 10]B(n,[alpha])[sup 7]Li reaction with p- boronophenylalanine was higher than that with any other boron compound tested. Generally accepted RBE values for the fast neutron and [sup 14]N(n,p)[sup 14]C reaction components of the totals are too low. The apparent RBEs calculated for the [sup 10]B(n,[alpha])[sup 7]Li reaction were compound-dependent and consistent with differences in the distribution of [sup 10]B relative to glioma cell nuclei. 39 refs., 2 figs., 3 tabs.

• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6568829
• Journal Information: International Journal of Radiation Oncology, Biology and Physics; (United States), Journal Name: International Journal of Radiation Oncology, Biology and Physics; (United States) Vol. 27:5; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BORON 10
BORON ISOTOPES
CARBON 14
CARBON ISOTOPES
CHARGED-PARTICLE REACTIONS
EVEN-EVEN NUCLEI
HEAVY ION REACTIONS
ISOTOPES
LIGHT NUCLEI
LITHIUM 7
LITHIUM ISOTOPES
MEDICINE
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NITROGEN 14 REACTIONS
NUCLEAR MEDICINE
NUCLEAR REACTIONS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RBE
STABLE ISOTOPES
THERAPY
YEARS LIVING RADIOISOTOPES