Major compound-dependent variations of sup 10 B(n. alpha. ) sup 7 Li RBE for the 9L RAT gliosarcoma in vitro and in vivo

Conference · Tue Jan 01 04:00:00 EST 1991

OSTI ID:5742370

Coderre, J A; Makar, M S; Micca, P L; Nawrocky, M M; Joel, D D; Slatkin, D N

Relative biological effectiveness (RBE) values for the high linear-energy-transfer (LET) radiations produced during born neutron capture therapy (BNCT) were determined using the 9L rat gliosarcorna both in vitro and as an intracerebral tumor. In the absence of {sup 10}B, the combined effect of the recoiling protons from the {sup 14}N(n,p){sup 14}C and the {sup 1}H(n,n{prime})p reactions, compared to an iso-effect endpoint produced by 250 kVp x-rays, yielded RBEs for these high-LET protons of 4.4 in vitro and 3.8 in an in vivo/in vitro assay. RBEs for the {sup 10}B(n,{alpha}){sup 7}Li reaction were calculated from cell survival data following reactor irradiation in the presence or in the absence of the either of the amino acid, p-boronophenylalanine (BPA) or the sulfhydryl dodecaborane dimer (BSSB). With BPA, RBE values ranged from 3.5 to 11.4, while under the same set of conditions with BSSB, RBE values ranged from 1.1 to 4.3. In vitro, higher RBEs for the {sup 10}B(n,{alpha}){sup 7}Li reaction using BPA than with BSSB suggest a difference in distribution of {sup 10}B relative to the nucleus.

• Research Organization: Brookhaven National Lab., Upton, NY (United States)
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 5742370
• Report Number(s): BNL-47080; CONF-9109343--1; ON: DE92007608
• Country of Publication: United States
• Language: English

Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL ISOTOPES
ANIMALS
BORON 10
BORON ISOTOPES
DISEASES
ISOTOPES
LIGHT NUCLEI
LITHIUM 7
LITHIUM ISOTOPES
MAMMALS
MEDICINE
NEOPLASMS
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
RADIOLOGY
RADIOTHERAPY
RATS
RODENTS
SARCOMAS
STABLE ISOTOPES
THERAPY
VERTEBRATES