Imaging of experimental myocardial infarction with technetium-99m 2,3-dimercaptosuccinic acid

Journal Article · Sat Feb 28 23:00:00 EST 1981 · J. Nucl. Med.; (United States)

OSTI ID:6568591

Karlsberg, R P; Milne, N; Lyons, K P; Aronow, W S

We have studied the use of Tc-99m-labeled 2,3-dimercaptosuccinic acid(Tc-99m DMSA) to scintigraph acute myocardial infaction after coronary occlusion in dogs. Optimal images were obtained 5 hr after injection of radiotracer, with consistent delineation 48 hr after occlusion. Delivery of tracer was dependent on blood flow. Uptake of tracer correlated to extent of infarction as determined by the myocardial depletion of creatine kinase. Myocardial Tc-99m DMSA was protein-bound.

• Research Organization: Veterans Administration Medical Center, Long Beach, CA
• OSTI ID: 6568591
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:3; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMISTRY
BLOOD FLOW
BLOOD-PLASMA CLEARANCE
BODY
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEMISTRY
CLEARANCE
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DICARBOXYLIC ACIDS
DISEASES
DISTRIBUTION
DOGS
ESTERS
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
METABOLISM
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
SCINTISCANNING
SUCCINIC ACID
TECHNETIUM 99
TECHNETIUM ISOTOPES
TIME DEPENDENCE
TISSUE DISTRIBUTION
UPTAKE
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES