Imaging of experimental myocardial infarction with technetium-99m 2,3-dimercaptosuccinic acid

Journal Article · Sun Mar 01 00:00:00 EST 1981 · J. Nucl. Med.; (United States)

OSTI ID:6568591

Karlsberg, R P; Milne, N; Lyons, K P; Aronow, W S

We have studied the use of Tc-99m-labeled 2,3-dimercaptosuccinic acid(Tc-99m DMSA) to scintigraph acute myocardial infaction after coronary occlusion in dogs. Optimal images were obtained 5 hr after injection of radiotracer, with consistent delineation 48 hr after occlusion. Delivery of tracer was dependent on blood flow. Uptake of tracer correlated to extent of infarction as determined by the myocardial depletion of creatine kinase. Myocardial Tc-99m DMSA was protein-bound.

• Research Organization: Veterans Administration Medical Center, Long Beach, CA
• OSTI ID: 6568591
• Journal Information: J. Nucl. Med.; (United States), Vol. 22:3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
MYOCARDIAL INFARCTION
DIAGNOSIS
MYOCARDIUM
SCINTISCANNING
TECHNETIUM 99
DIAGNOSTIC USES
BIOCHEMISTRY
BLOOD FLOW
BLOOD-PLASMA CLEARANCE
CARBOXYLIC ACID ESTERS
DOGS
ISOMERIC NUCLEI
LABELLED COMPOUNDS
METABOLISM
RADIONUCLIDE KINETICS
SUCCINIC ACID
TIME DEPENDENCE
TISSUE DISTRIBUTION
UPTAKE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEMISTRY
CLEARANCE
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DICARBOXYLIC ACIDS
DISEASES
DISTRIBUTION
ESTERS
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM ISOTOPES
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550901 - Pathology- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques