Observations on cattle schistosomiasis in the Sudan, a study in comparative medicine. III. Field testing of an irradiated Schistosoma bovis vaccine
Previous work has shown that cattle can acquire a strong resistance to Schistosoma bovis infection following repeated natural exposure. Partial resistance to a laboratory challenge with S. bovis has also been demonstrated in calves after immunization with an irradiated schistosomular or cercarial vaccine. The aim of the present study was to see whether this type of caccine could protect calves under the very different conditions of natural exposure to S. bovis in the field. Thirty 6- to 9-month-old calves were each immunized with 10,000 irradiated S. bovis schistosomula by intramuscular injection and 8 weeks later were released into an enzootic area along with 30 unvaccinated animals. The calves were followed up for 10 months, during which period protection was evidenced by a lower mortality rate, a slower rate of acquisition of infection, and lower fecal egg counts in the vaccinated calves. Necropsy of the survivors showed 60 to 70% reductions in worm and tissue egg counts of the vaccinated calves as compared to those not vaccinated.
- Research Organization:
- Univ. of Khartoum, Sudan
- OSTI ID:
- 6566527
- Journal Information:
- Am. J. Trop. Med. Hyg.; (United States), Vol. 29:3
- Country of Publication:
- United States
- Language:
- English
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SCHISTOSOMA
VACCINES
BIOLOGICAL RADIATION EFFECTS
CALVES
CATTLE
COMPARATIVE EVALUATIONS
INOCULATION
INTRAMUSCULAR INJECTION
SCHISTOSOMIASIS
SUDAN
AFRICA
ANIMALS
BIOLOGICAL EFFECTS
DEVELOPING COUNTRIES
DISEASES
DOMESTIC ANIMALS
HELMINTHS
INFECTIOUS DISEASES
INJECTION
INTAKE
MAMMALS
PARASITIC DISEASES
PLATYHELMINTHS
RADIATION EFFECTS
RUMINANTS
TREMATODES
VERTEBRATES
560134* - Radiation Effects on Microorganisms- Vaccine Preparation & Other Applications- (-1987)