Radiation-induced pulmonary arterial perfusion defects: modification by D-penicillamine. [Rats; /sup 60/Co]

Conference · Wed Apr 01 04:00:00 EST 1981 · Radiology; (United States)

OSTI ID:6566328

Ward, W F

D-penicillamine, previously shown to have a beneficial effect on radiation-induced pulmonary histopathology, was tested to determine its effect on function in the irradiated lung. Male rats were irradiated with /sup 60/Co gamma rays; half then received 10 mg D-penicillamine per day, and half received no further treatment. One to nine months after irradiation, animals were subjected to lung perfusion scans. Untreated irradiated rats exhibited hyperemia, hypoperfusion, and perfusion defects of the irradiated lung. In penicillamine-treated rats, the appearance of perfusion defects was delayed, the peak incidence and severity of the defects was reduced, and recovery from pulmonary hypoperfusion was accelerated. Thus, using functional criteria, penicillamine appears to improve arterial perfusion and to ameliorate radiation injury in the rat lung.

• Research Organization: Northwestern Univ., Chicago, IL
• OSTI ID: 6566328
• Conference Information: Journal Name: Radiology; (United States) Journal Volume: 139:1
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
COBALT 60
COBALT ISOTOPES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DRUGS
ELECTROMAGNETIC RADIATION
EVALUATION
GAMMA RADIATION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PENICILLAMINE
PERFUSED ORGANS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RATS
RESPIRATORY SYSTEM
RODENTS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
THIOLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES