Radiation injury in rat lung. IV. Modification by d-penicillamine

Journal Article · Tue May 01 04:00:00 EDT 1984 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576247· OSTI ID:7054456

Ward, W F; Molteni, A; Ts'ao, C; Solliday, N H

To determine whether d-penicillamine, known to reduce fibrosis in irradiated rat lung, also ameliorates radiation injury in the pulmonary endothelium, the authors measured angiotensin-converting enzyme (ACE) activity, plasminogen activator (PLA) activity, and prostacyclin (PGI/sub 2/) production in the lungs of penicillamine-treated and untreated rats from 2 weeks to 6 months after a single dose of 25 Gy of /sup 60/Co ..gamma.. rays to the right hemithorax. Both ACE and PLA activity in the irradiated right lung of untreated rats decreased dramatically between the 1st and 2nd months after exposure, then reached a plateau through 6 months at approximately 25 and 50% of the normal level, respectively. For the first 2 months after irradiation, penicillamine-treated animals exhibited significantly higher activites of both ACE and PLA than did untreated rats. From 3 to 6 months after irradiation, however, the only significant drug effect on these enzymes was a 25% increase in PLA activity at 6 months. PGI/sub 2/ production by the irradiated lung of untreated rats increased continuously, and at 6 months was approximately 10 times higher than normal. Penicillamine significantly reduced this hypersecretion, and at 6 months after irradiation, PGI/sub 2/ production by the lungs of drug-treated rats was only half that of untreated animals. Thus the antifibrotic agent d-penicillamine delays the onset of radiation-induced enzyme dysfunction in the pulmonary endothelium.

• Research Organization: Northwestern Univ. Medical School, Chicago, IL
• OSTI ID: 7054456
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 98:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CHEMISTRY
COBALT 60
COBALT ISOTOPES
DELAYED RADIATION EFFECTS
DRUGS
EARLY RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
FIBRINOLYTIC AGENTS
GAMMA RADIATION
HEMATOLOGIC AGENTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PENICILLAMINE
PLASMINOGEN
PROSTAGLANDINS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RATS
RESPIRATORY SYSTEM
RODENTS
THIOLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES