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Effects of x rays and fission neutrons on an induced proliferative response in lung type 2 epithelial cells

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3575571· OSTI ID:6565251
The recovery of the proliferative response induced by butylated hydroxytoluene (BHT) was evaluated in the type 2 epithelial cell population of BALB/c mouse lung after x-ray or fission neutron irradiation. Previous autoradiographic studies revealed that the proliferative changes in the lung 2 days after BHT administration were due primarily to type 2 alveolar cells. When given immediately before BHT, radiation caused a dose-dependent decrease in the BHT-induced proliferative response, measured by (/sup 14/C)thymidine incorporation into DNA and by labeling studies. When the time between irradiation and BHT injection was lengthened, the proliferative response gradually returned in a dose-dependent manner. Two types of recovery processes were investigated.
Research Organization:
Oak Ridge National Lab., TN
DOE Contract Number:
W-7405-ENG-26
OSTI ID:
6565251
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 85:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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