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Title: Nuclear medicine program progress report for quarter ending December 31, 1996

Abstract

In this report the authors describe the use of an effective method for concentration of the rhenium-188 bolus and the results of the first Phase 1 clinical studies for bone pain palliation with rhenium-188 obtained from the tungsten-188/rhenium-188 generator. Initial studies with therapeutic levels of Re-188-HEDP at the Clinic for Nuclear Medicine at the University of Bonn, Germany, have demonstrated the expected good metastatic uptake of Re-188-HEDP in four patients who presented with skeletal metastases from disseminated prostatic cancer with good pain palliation and minimal marrow suppression. In addition, skeletal metastatic targeting of tracer doses of Re-188(V)-DMSA has been evaluated in several patients with metastases from prostatic cancer at the Department of Nuclear Medicine at the Canterbury and Kent Hospital in Canterbury, England. In this report the authors also describe further studies with the E-(R,R)-IQNP ligand developed in the ORNL Nuclear Medicine Program as a potential imaging agent for detection of changes which may occur in the cerebral muscarinic-cholinergic receptors (mAChR) in Alzheimer`s and other diseases.

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Oak Ridge National Lab., TN (United States)
Sponsoring Org.:
USDOE Office of Energy Research, Washington, DC (United States)
OSTI Identifier:
656448
Report Number(s):
ORNL/TM-13353
ON: DE98003638; TRN: AHC29817%%2
DOE Contract Number:  
AC05-96OR22464
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: 20 Mar 1997
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; 40 CHEMISTRY; PROGRESS REPORT; RHENIUM 188; RADIOTHERAPY; NUCLEAR MEDICINE; RESEARCH PROGRAMS; LIGANDS; RADIOPHARMACEUTICALS; RADIOISOTOPE GENERATORS; EXPERIMENTAL DATA

Citation Formats

Knapp, Jr, F F, Beets, A L, Boll, R, Luo, H, McPherson, D W, and Mirzadeh, S. Nuclear medicine program progress report for quarter ending December 31, 1996. United States: N. p., 1997. Web. doi:10.2172/656448.
Knapp, Jr, F F, Beets, A L, Boll, R, Luo, H, McPherson, D W, & Mirzadeh, S. Nuclear medicine program progress report for quarter ending December 31, 1996. United States. doi:10.2172/656448.
Knapp, Jr, F F, Beets, A L, Boll, R, Luo, H, McPherson, D W, and Mirzadeh, S. Thu . "Nuclear medicine program progress report for quarter ending December 31, 1996". United States. doi:10.2172/656448. https://www.osti.gov/servlets/purl/656448.
@article{osti_656448,
title = {Nuclear medicine program progress report for quarter ending December 31, 1996},
author = {Knapp, Jr, F F and Beets, A L and Boll, R and Luo, H and McPherson, D W and Mirzadeh, S},
abstractNote = {In this report the authors describe the use of an effective method for concentration of the rhenium-188 bolus and the results of the first Phase 1 clinical studies for bone pain palliation with rhenium-188 obtained from the tungsten-188/rhenium-188 generator. Initial studies with therapeutic levels of Re-188-HEDP at the Clinic for Nuclear Medicine at the University of Bonn, Germany, have demonstrated the expected good metastatic uptake of Re-188-HEDP in four patients who presented with skeletal metastases from disseminated prostatic cancer with good pain palliation and minimal marrow suppression. In addition, skeletal metastatic targeting of tracer doses of Re-188(V)-DMSA has been evaluated in several patients with metastases from prostatic cancer at the Department of Nuclear Medicine at the Canterbury and Kent Hospital in Canterbury, England. In this report the authors also describe further studies with the E-(R,R)-IQNP ligand developed in the ORNL Nuclear Medicine Program as a potential imaging agent for detection of changes which may occur in the cerebral muscarinic-cholinergic receptors (mAChR) in Alzheimer`s and other diseases.},
doi = {10.2172/656448},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {3}
}