Influence of nandrolone decanoate on the repopulation of the thymus after total body irradiation of mice
Journal Article
·
· Immunopharmacology; (United States)
It has been reported that nandrolone decanoate is helpful in overcoming the neutropenic phase following irradiation. In the present study the influence of nandrolone decanoate on the thymus' cellularity after total body irradiation was investigated. In comparison with a placebo-treated group, mice receiving nandrolone decanoate showed a similar pattern of thymus repopulation, but a significantly lower number of thymocytes over the whole period of treatment was found. Nonirradiated mice also had a significantly lower number of thymocytes when treated with nandrolone decanoate. In addition, the number of circulating leukocytes was also evaluated over a period of 1 month after total body irradiation. On 11 of the 21 days investigated, a significantly higher number of leukocytes was found in the nandrolone decanoate-treated group. We conclude that the action of nandrolone decanoate was not clearly distinct from that of testosterone regarding either granulopoiesis or thymic involution.
- Research Organization:
- Laboratorium voor Bacteriologie en Virologie, Akademisch Ziekenhuis, Ghent, Belgium
- OSTI ID:
- 6562692
- Journal Information:
- Immunopharmacology; (United States), Journal Name: Immunopharmacology; (United States) Vol. 5:1; ISSN IMMUD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Enhancement of committed hematopoietic stem cell colony formation by nandrolone decanoate after sublethal whole body irradiation
Influence of MHC on thymus repopulation following intrathymic transfer of mouse T-cell precursors
Phenotypic characterization of early events of thymus repopulation in radiation bone marrow chimeras
Journal Article
·
Wed Oct 31 23:00:00 EST 1984
· Int. J. Cell Cloning; (United States)
·
OSTI ID:5825556
Influence of MHC on thymus repopulation following intrathymic transfer of mouse T-cell precursors
Journal Article
·
Tue Mar 31 23:00:00 EST 1987
· Cell. Immunol.; (United States)
·
OSTI ID:6467328
Phenotypic characterization of early events of thymus repopulation in radiation bone marrow chimeras
Journal Article
·
Thu Mar 31 23:00:00 EST 1983
· Transplantation; (United States)
·
OSTI ID:5762338
Related Subjects
550300 -- Cytology
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBOXYLIC ACID ESTERS
CELL PROLIFERATION
ESTERS
EXTERNAL IRRADIATION
IMMUNOLOGY
IRRADIATION
LEUKOCYTES
LYMPHATIC SYSTEM
MAMMALS
MATERIALS
MICE
NEUTROPHILS
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RODENTS
THYMUS
VERTEBRATES
WHOLE-BODY IRRADIATION
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBOXYLIC ACID ESTERS
CELL PROLIFERATION
ESTERS
EXTERNAL IRRADIATION
IMMUNOLOGY
IRRADIATION
LEUKOCYTES
LYMPHATIC SYSTEM
MAMMALS
MATERIALS
MICE
NEUTROPHILS
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RODENTS
THYMUS
VERTEBRATES
WHOLE-BODY IRRADIATION