Pathogenesis of progressive rod-cone degeneration in miniature poodles

Journal Article · Mon Nov 01 04:00:00 EST 1982 · Invest. Ophthalmol. Visual Sci.; (United States)

OSTI ID:6562303

Aguirre, G; Alligood, J; O'Brien, P; Buyukmihci, N

Visual cell pathologic changes and outer segment renewal were investigated in miniature poodles with progressive rod-cone degeneration. Early in this disease, visual cells in the posterior pole and equatorial regions show outer segment lamellar disorientation and vesicular profiles. Visual cells are normal in the periphery. Outer segment renewal determined after intravitreal injection of /sup 3/H-leucine was abnormally slower in affected animals than in controls. This renewal abnormality was similar in structurally normal and diseased photoreceptors, suggesting that the renewal defect is the earliest recognizable abnormality in the disease. The pigment epithelium was normal; the presence and density of pigment did not appear to affect the extent and severity of the disease or modify the abnormal renewal rate. As the disease progressed, photoreceptor outer segments were lost, and the remaining diminutive photoreceptors accumulated label in the inner segment and perinuclear zones. Sodium dodecyl sulfate gel electrophoresis of crude rod outer segment preparations showed no differences in opsin synthesis between normal and affected retinas early in the disease, but opsin synthesis decreased in the late stage of the disease.

• Research Organization: School of Veterinary Medicine, University of Pennsylvania, Philadelphia
• OSTI ID: 6562303
• Journal Information: Invest. Ophthalmol. Visual Sci.; (United States), Journal Name: Invest. Ophthalmol. Visual Sci.; (United States) Vol. 23:5; ISSN IOVSD
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMALS
BIOLOGICAL PATHWAYS
BODY
BODY AREAS
CARBOXYLIC ACIDS
DISEASES
DOGS
EYES
FACE
HEAD
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LEUCINE
MAMMALS
MEDICINE
OPHTHALMOLOGY
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PATHOLOGY
RETINA
SENSE ORGANS
SENSE ORGANS DISEASES
TRITIUM COMPOUNDS
VERTEBRATES
VISION