The sunburn cell in hairless mouse epidermis: quantitative studies with UV-A radiation and mono- and bifunctional psoralens

Journal Article · Fri Oct 01 00:00:00 EDT 1982 · J. Invest. Dermatol.; (United States)

DOI:https://doi.org/10.1111/1523-1747.ep12500064· OSTI ID:6561869

Young, A R; Magnus, I A

The production of the sunburn cell by UV-A radiation and topical psoralens in hairless mouse epidermis has been studied. It has been shown that the appearance of this cell is dependent on the dose of both UV-A radiation and of the psoralen. The time-course with 8-methoxypsoralen has peak sunburn cell numbers at 28 hr postirradiation. A comparison of 2 bifunctional (8-methoxypsoralen and 5-methoxypsoralen) and 2 monofunctional (angelicin and 3-carbethoxypsoralen) psoralens showed the former are more potent. This suggests that DNA crosslink lesions may play a rle in sunburn cell production.

• Research Organization: Department of Photobiology, Institute of Dermatology, London, England
• OSTI ID: 6561869
• Journal Information: J. Invest. Dermatol.; (United States), Vol. 79:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
EPIDERMIS
BIOLOGICAL RADIATION EFFECTS
PSORALEN
RADIOSENSITIVITY EFFECTS
BIOLOGICAL PATHWAYS
DOSE-RESPONSE RELATIONSHIPS
MICE
RADIATION DOSES
ULTRAVIOLET RADIATION
ANIMAL TISSUES
ANIMALS
ANTICOAGULANTS
BIOLOGICAL EFFECTS
BODY
COUMARINS
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
EPITHELIUM
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
SKIN
TISSUES
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)