The sunburn cell in hairless mouse epidermis: quantitative studies with UV-A radiation and mono- and bifunctional psoralens
Journal Article
·
· J. Invest. Dermatol.; (United States)
The production of the sunburn cell by UV-A radiation and topical psoralens in hairless mouse epidermis has been studied. It has been shown that the appearance of this cell is dependent on the dose of both UV-A radiation and of the psoralen. The time-course with 8-methoxypsoralen has peak sunburn cell numbers at 28 hr postirradiation. A comparison of 2 bifunctional (8-methoxypsoralen and 5-methoxypsoralen) and 2 monofunctional (angelicin and 3-carbethoxypsoralen) psoralens showed the former are more potent. This suggests that DNA crosslink lesions may play a rle in sunburn cell production.
- Research Organization:
- Department of Photobiology, Institute of Dermatology, London, England
- OSTI ID:
- 6561869
- Journal Information:
- J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 79:4; ISSN JIDEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
ANTICOAGULANTS
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BODY
COUMARINS
DOSE-RESPONSE RELATIONSHIPS
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
EPIDERMIS
EPITHELIUM
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PSORALEN
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SKIN
TISSUES
ULTRAVIOLET RADIATION
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
ANTICOAGULANTS
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BODY
COUMARINS
DOSE-RESPONSE RELATIONSHIPS
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
EPIDERMIS
EPITHELIUM
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PSORALEN
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SKIN
TISSUES
ULTRAVIOLET RADIATION
VERTEBRATES