Local regulation of blood flow evaluated simultaneously by 133-xenon washout and laser Doppler flowmetry

Journal Article · Tue Nov 01 04:00:00 EST 1988 · J. Invest. Dermatol.; (United States)

DOI:https://doi.org/10.1111/1523-1747.ep12476572· OSTI ID:6558324

Engelhart, M; Petersen, L J; Kristensen, J K

The laser Doppler flowmeter and the 133-Xenon washout techniques of measuring cutaneous blood flow were compared for measuring the vasoconstrictor response of the hand during orthostatic maneuvres. Important discrepancies were detected for the two methods. When the hand was lowered by 40 cm a 40% decrease in blood flow was detected by the 133-Xenon method, while a 60% decrease was seen by the laser Doppler technique. Lowering the hand by 50 cm resulted in no further blood flow decrease when using the 133-Xenon method, but an 80% blood flow decrease was recorded with the laser Doppler method. A marked decrease in blood flow was recorded by the laser Doppler technique in hands that were sympathectomized or a hand that was subjected to a nerve blockade, strategies which should eliminate the orthostatic vasoconstrictor response of superficial cutaneous vessels. The 133-Xenon technique did not detect any blood flow changes in hands without sympathetic tone. We found the laser Doppler flowmetry technique unsatisfactory for measurement of blood flow changes that occur in nutritional vessels as this method measures total skin blood flow including non-capillary vessels.

• Research Organization: Univ. of Copenhagen Rigshospital (Denmark)
• OSTI ID: 6558324
• Journal Information: J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 91:5; ISSN JIDEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BODY AREAS
DAYS LIVING RADIOISOTOPES
DYNAMIC FUNCTION STUDIES
EVEN-ODD NUCLEI
HANDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIMBS
NERVES
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
SKIN
TRACER TECHNIQUES
VASOCONSTRICTION
XENON 133
XENON ISOTOPES