Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Regional heterogeneity of myocardial blood flow detected and quantified by Xenon-133 washout analysis in patients with coronary artery disease

Conference · · J. Nucl. Med.; (United States)
OSTI ID:6548348
; ;
The Xenon-133 washout technique has been used to measure myocardial blood flow (MBF). However, controversy exists regarding the ability of the method to detect regional heterogeneity of MBF. The authors measured MBF (ml/100gm/min) in the circumflex and anterior descending arteries after injection of 12-15 mCi Xenon-133 in saline into the left coronary of 12 patients. Each patient had one diseased branch (greater than or equal to75% stenosis) and one normal branch (0-30% stenosis) of the left coronary. Control flow (C-MBF) was measured and flow was remeasured after 0.15 mg/kg/min x 4 min. intravenous dipyridamole (D-MBF). Coronary resistance (Res) was calculated as mean aortic pressure/MBF. After dipyridamole, significant regional heterogeneity of tracer uptake was seen on the Xenon images. MBF in the diseased artery was markedly lower and resistance higher compared to the normal artery. The ratio of D-MBF in the diseased vessel to D-MBF in the normal vessel was 0.64+-13. The data obtained provide unequivocal evidence that this technique can detect and quantitate regional heterogeneity of coronary flow even when low flow areas are contiguous with high flow areas.
Research Organization:
Univ. of Wisconsin Medical School, Mount Sinai Medical Center, Milwaukee, WI
OSTI ID:
6548348
Report Number(s):
CONF-840619-
Conference Information:
Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
Country of Publication:
United States
Language:
English

Similar Records

Quantitative thallium-201 single photon emission computed tomography after oral dipyridamole for assessing the presence, anatomic location and severity of coronary artery disease
Journal Article · Sun May 01 00:00:00 EDT 1988 · J. Am. Coll. Cardiol.; (United States) · OSTI ID:6994092
Quantitative thallium-201 single photon emission computed tomography after oral dipyridamole for assessing the presence, anatomic location and severity of coronary artery disease
Journal Article · Sun May 01 00:00:00 EDT 1988 · J. Am. Coll. Cardiol.; (United States) · OSTI ID:7154224
The variable extent of jeopardized myocardium in patients with single vessel coronary artery disease: Quantification by thallium-201 single photon emission computed tomography
Journal Article · Thu Jan 31 23:00:00 EST 1991 · Journal of the American College of Cardiology; (USA) · OSTI ID:6060414

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD VESSELS
BODY
CARDIOGRAPHY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CORONARIES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DETECTION
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
DYNAMIC FUNCTION STUDIES
EVEN-ODD NUCLEI
HEART
IMAGES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MUSCLES
MYOCARDIUM
NUCLEI
ORGANS
RADIOCARDIOGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
TRACER TECHNIQUES
UPTAKE
XENON 133
XENON ISOTOPES