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Title: Scintigraphic and electrophysiological evidence of canine myocardial sympathetic denervation and reinnervation produced by myocardial infarction or phenol application

Abstract

Epicardial phenol application or transmural myocardial infarction in dogs produces sympathetic denervation of myocardium apical to the site of the intervention. Because efferent denervation is probably postganglionic, reinnervation most likely occurs but has not been shown. We investigated whether 123I-labeled metaiodobenzylguanidine (MIBG), a norepinephrine analogue taken up by sympathetic nerve terminals, could provide a scintigraphic image that would detect apical sympathetic denervation and possible reinnervation. Dogs underwent MIBG scintigraphic imaging at various times after phenol application or transmural myocardial infarction. The results of MIBG scintigraphy were correlated with electrophysiological responses obtained during ansae subclaviae and norepinephrine stimulation to establish the presence of neural denervation and reinnervation. Apical defects in the MIBG scan, which were associated with either normal perfusion by thallium or a smaller-sized defect, were found consistently in dogs that had apical sympathetic innervation. MIBG scintigraphic images returned to normal after 14 weeks (mean) at a time when reinnervation was shown to have occurred. Thus, the results of MIBG scintigraphy correlated accurately with the presence of denervation and reinnervation established by neuroelectrophysiological testing. Supersensitive refractory period shortening in response to norepinephrine infusion was present after denervation and persisted for more than 3 weeks after scintigraphic and electrophysiological evidence ofmore » reinnervation. Conclusions are that 1) MIBG can be used noninvasively to determine the presence of regional myocardial efferent sympathetic denervation and subsequent reinnervation, 2) reinnervation occurs after phenol application or transmural myocardial infarction, and 3) denervation supersensitivity persists even after reinnervation occurs.« less

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Indiana Univ. School of Medicine, Indianapolis (USA)
OSTI Identifier:
6558295
Resource Type:
Journal Article
Resource Relation:
Journal Name: Circulation; (United States); Journal Volume: 78:4
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HEART; SCINTISCANNING; NERVES; BIOLOGICAL REGENERATION; PHENOLS; BIOLOGICAL EFFECTS; DOGS; ELECTROPHYSIOLOGY; IMAGE PROCESSING; IODINE 123; MYOCARDIAL INFARCTION; PERFUSED ORGANS; RADIOPHARMACEUTICALS; ANIMALS; AROMATICS; BETA DECAY RADIOISOTOPES; BIOLOGICAL RECOVERY; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PHYSIOLOGY; PROCESSING; RADIOISOTOPE SCANNING; RADIOISOTOPES; RECOVERY; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 560300 - Chemicals Metabolism & Toxicology

Citation Formats

Minardo, J.D., Tuli, M.M., Mock, B.H., Weiner, R.E., Pride, H.P., Wellman, H.N., and Zipes, D.P. Scintigraphic and electrophysiological evidence of canine myocardial sympathetic denervation and reinnervation produced by myocardial infarction or phenol application. United States: N. p., 1988. Web. doi:10.1161/01.CIR.78.4.1008.
Minardo, J.D., Tuli, M.M., Mock, B.H., Weiner, R.E., Pride, H.P., Wellman, H.N., & Zipes, D.P. Scintigraphic and electrophysiological evidence of canine myocardial sympathetic denervation and reinnervation produced by myocardial infarction or phenol application. United States. doi:10.1161/01.CIR.78.4.1008.
Minardo, J.D., Tuli, M.M., Mock, B.H., Weiner, R.E., Pride, H.P., Wellman, H.N., and Zipes, D.P. Sat . "Scintigraphic and electrophysiological evidence of canine myocardial sympathetic denervation and reinnervation produced by myocardial infarction or phenol application". United States. doi:10.1161/01.CIR.78.4.1008.
@article{osti_6558295,
title = {Scintigraphic and electrophysiological evidence of canine myocardial sympathetic denervation and reinnervation produced by myocardial infarction or phenol application},
author = {Minardo, J.D. and Tuli, M.M. and Mock, B.H. and Weiner, R.E. and Pride, H.P. and Wellman, H.N. and Zipes, D.P.},
abstractNote = {Epicardial phenol application or transmural myocardial infarction in dogs produces sympathetic denervation of myocardium apical to the site of the intervention. Because efferent denervation is probably postganglionic, reinnervation most likely occurs but has not been shown. We investigated whether 123I-labeled metaiodobenzylguanidine (MIBG), a norepinephrine analogue taken up by sympathetic nerve terminals, could provide a scintigraphic image that would detect apical sympathetic denervation and possible reinnervation. Dogs underwent MIBG scintigraphic imaging at various times after phenol application or transmural myocardial infarction. The results of MIBG scintigraphy were correlated with electrophysiological responses obtained during ansae subclaviae and norepinephrine stimulation to establish the presence of neural denervation and reinnervation. Apical defects in the MIBG scan, which were associated with either normal perfusion by thallium or a smaller-sized defect, were found consistently in dogs that had apical sympathetic innervation. MIBG scintigraphic images returned to normal after 14 weeks (mean) at a time when reinnervation was shown to have occurred. Thus, the results of MIBG scintigraphy correlated accurately with the presence of denervation and reinnervation established by neuroelectrophysiological testing. Supersensitive refractory period shortening in response to norepinephrine infusion was present after denervation and persisted for more than 3 weeks after scintigraphic and electrophysiological evidence of reinnervation. Conclusions are that 1) MIBG can be used noninvasively to determine the presence of regional myocardial efferent sympathetic denervation and subsequent reinnervation, 2) reinnervation occurs after phenol application or transmural myocardial infarction, and 3) denervation supersensitivity persists even after reinnervation occurs.},
doi = {10.1161/01.CIR.78.4.1008},
journal = {Circulation; (United States)},
number = ,
volume = 78:4,
place = {United States},
year = {Sat Oct 01 00:00:00 EDT 1988},
month = {Sat Oct 01 00:00:00 EDT 1988}
}