Experimental increase in brain HIPDM uptake by hypercapnia

Journal Article · Sat Oct 01 04:00:00 EDT 1988 · J. Nucl. Med.; (United States)

OSTI ID:6558158

Karatzas, N D; Sfakianakis, G N; Pappas, D; Duncan, R; Heal, A; Serafini, A; Kung, H F

The 30-min brain uptake of (/sup 125/I)HIPDM was measured in conscious rats--normocapnic (n = 8), hypercapnic (n = 12), and hyperoxic (n = 6). A mean 41.2% higher uptake was found in the brains of hypercapnic animals (p less than 0.01). In the three groups of rats, brain HIPDM uptake had a negative correlation with body weight (p less than 0.001) and a positive correlation with arterial pCO/sub 2/ (p less than 0.01), when adjusted for body weight. These results indicate that HIPDM uptake with hypercapnia may be used as a provocative test to measure cerebral blood flow reserves.

• Research Organization: Univ. of Miami School of Medicine, FL (USA)
• OSTI ID: 6558158
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 29:10; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RODENTS
UPTAKE
VERTEBRATES