Abnormal captopril renogram with a technetium-99m-labeled hippuran analog
A case of renovascular hypertension is presented in which the (/sup 131/I)hippuran renogram was initially normal, but became strikingly abnormal upon administration of the angiotensin converting enzyme (ACE) inhibitor captopril. The patient presented with fibromuscular dysplasia of the renal arteries, which was shown by hippuran renography to be functionally significant on the right side. She became normotensive after angioplasty of the right renal artery. Hypertension recurred a year later, at which time the renogram was normal without captopril, but showed functionally significant left renal artery stenosis with captopril challenge. Both the conventional agent, (/sup 131/I)hippuran, and an experimental new /sup 99m/Tc-labeled hippuran analog, (/sup 99m/Tc)MAG3, were used. Angiography confirmed progression of disease on the left side, which was successfully treated by angioplasty. Functionally significant unilateral renal artery stenosis was thus demonstrated first on the right side and then, 1 yr later, on the left side, using hippuran and (/sup 99m/Tc)MAG3. Anatomic progression of disease was documented by angiography.
- Research Organization:
- Univ. of Alabama Hospital, Birmingham (USA)
- OSTI ID:
- 6558065
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 29:10
- Country of Publication:
- United States
- Language:
- English
Similar Records
Captopril induced renographic alteration in unilateral renal artery stenosis
Single visit captopril renography for the diagnosis of curable renovascular hypertension (RVH)
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
HYPERTENSION
PATHOGENESIS
KIDNEYS
BIOMEDICAL RADIOGRAPHY
UROGENITAL SYSTEM DISEASES
DIAGNOSIS
ANTIHYPERTENSIVE AGENTS
ENZYME INHIBITORS
HIPPURAN
IODINE 131
ISOMERIC NUCLEI
ORGANOMETALLIC COMPOUNDS
PATIENTS
TECHNETIUM 99
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CONTRAST MEDIA
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOLOGY
SYMPTOMS
TECHNETIUM ISOTOPES
VASCULAR DISEASES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550901 - Pathology- Tracer Techniques