Captopril induced renographic alteration in unilateral renal artery stenosis

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6405300

Oei, H Y; Geyskes, G G; Dorhout Mees, E J; Puijlaert, C B.A.J.

In patients with unilateral renal artery stenosis (URAS) captopril administration will deteriorate glomerular filtration in the affected kidney by interruption of autoregulatory mechanisms. This effect might be detectable on renography and could be useful for the diagnosis of renovascular hypertension. After discontinuation of all medication, Tc-99m diethylene triamine pentaacetic acid (DTPA) gammacamera renography, followed by I-131 orthoiodohippurate (OIH) renography were performed in 15 hypertensive patients who were poorly controlled with medical therapy. This double examination was repeated some days later after administration of 25 mg captopril one hour prior to the examination. After this, angiography was done and patients with stenosis of the renal artery were treated by percutaneous transluminal dilatation (PTD). Five patients were excluded due to bilateral or segmental stenosis of the renal artery. Four URAS-patients, in whom the blood pressure improved after PTD, showed after administration of captopril a striking renographic alteration in the affected kidney. The DTPA-renogram which initially had an upslope phase, showed a blood disappearance curve and the OIH-renogram, which still had an upslope phase, showed a slower excretion. These renographic alteration did not occur in the other 2 URAS-patients, who had no benefit of the PTD and in the 4 remaining patients without stenosis. These findings suggest that captopril induced renographic alterations may be important for the diagnosis of hemodynamic significant URAS. For this purpose either DTPA or OIH can be used.

• Research Organization: Univ. Hospital, Utrecht
• OSTI ID: 6405300
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMISTRY
BIOMEDICAL RADIOGRAPHY
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEMISTRY
CLEARANCE
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DRUGS
DYNAMIC FUNCTION STUDIES
EXCRETION
FUNCTIONS
HOURS LIVING RADIOISOTOPES
HYPERTENSION
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOPHARMACEUTICALS
RENAL CLEARANCE
RENOGRAPHY
RETENTION FUNCTIONS
SCINTISCANNING
SYMPTOMS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
TRACER TECHNIQUES
UPTAKE
VASCULAR DISEASES
YEARS LIVING RADIOISOTOPES