Synthesis and body distribution of several iodine-313 labeled centrally acting drugs. [1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane; 4-iodo-2,5-dimethoxyphenylethylamine; rats, dogs]
Journal Article
·
· J. Med. Chem.; (United States)
1-(4-Iodo-2,5-dimethoxyphenyl)-2-aminopropane (3b), 4-iodo-2,5-dimethoxyphenylethylamine (3a), and 1-(4-iodo-2,5-dimethoxyphenyl)-2-aminobutane (3c) have been synthesized with /sup 131/I. Labeled iodine monochloride reacts with the appropriately substituted phthalimide at the aromatic 4 position, and the phthalic acid group is removed with hydrazine. Body distribution was measured in rats; the most prominent different between the three compounds was a much greater concentration in the lung with 3b than with 3a or 3c. ..gamma..-Ray scintigraphs of 3a-c in rats and of 3b in a dog indicate an uptake by the brain similar to that of the bromine analogue of 3b (DOB) in humans. (/sup 82/Br)-DOB has been suggested as a potential brain scanning agent for nuclear medicine; 3b would have the advantage over DOB of providing the superior ..gamma..-ray imaging properties of /sup 131/I or /sup 123/I.
- Research Organization:
- Univ. of California, Berkeley
- OSTI ID:
- 6550068
- Journal Information:
- J. Med. Chem.; (United States), Journal Name: J. Med. Chem.; (United States) Vol. 20:12; ISSN JMCMA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOSYNTHESIS
BODY
BRAIN
BROMINE 82
BROMINE ISOTOPES
CENTRAL NERVOUS SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLING
LUNGS
MAMMALS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RODENTS
SCINTISCANNING
SYNTHESIS
TISSUE DISTRIBUTION
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOSYNTHESIS
BODY
BRAIN
BROMINE 82
BROMINE ISOTOPES
CENTRAL NERVOUS SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLING
LUNGS
MAMMALS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RODENTS
SCINTISCANNING
SYNTHESIS
TISSUE DISTRIBUTION
VERTEBRATES