Effects of short-chain fatty acids on the neuronal membrane functions of Helix pomatia. III. /sup 22/Na efflux from the cells

Journal Article · Mon Dec 01 00:00:00 EST 1986 · Cell. Mol. Neurobiol.; (United States)

DOI:https://doi.org/10.1007/BF00711408· OSTI ID:6550003

Saghyan, A A; Dadalian, S S; Takenaka, T; Suleymanian, M A; Ayrapetyan, S N

The effect of short-chain fatty acids on both ouabain-sensitive and ouabain-insensitive fractions of /sup 22/Na efflux from the neurons of Helix pomatia was studied. Fatty acids, having fewer than 10 carbon atoms in the hydrocarbon chain, increased the ouabain-sensitive /sup 22/Na efflux from the neurons, while fatty acids, having more than 9 carbon atoms, inhibited the /sup 22/Na efflux in comparison with that in normal physiological solution. All the fatty acids used had an inhibiting effect on the ouabain-insensitive /sup 22/Na efflux from the cells independent on the number of carbon atoms in the hydrocarbon chain. These studies indicate that these short-chain fatty acids can be effective modulators of both ouabain-sensitive and ouabain-insensitive fractions of Na efflux from the cells.

• Research Organization: Institute of Experimental Biology, Yerevan, USSR
• OSTI ID: 6550003
• Journal Information: Cell. Mol. Neurobiol.; (United States), Vol. 4
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CARBOXYLIC ACIDS
BIOCHEMICAL REACTION KINETICS
SODIUM 22
MEMBRANE TRANSPORT
CELL MEMBRANES
IN VITRO
NERVE CELLS
OUABAIN
SNAILS
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
AQUATIC ORGANISMS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CELL CONSTITUENTS
DRUGS
GLYCOSIDES
INVERTEBRATES
ISOTOPES
KINETICS
LIGHT NUCLEI
MEMBRANES
MOLLUSCS
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOISOTOPES
REACTION KINETICS
SODIUM ISOTOPES
SOMATIC CELLS
STROPHANTHINS
YEARS LIVING RADIOISOTOPES
550301* - Cytology- Tracer Techniques