Effects of NO/sub 2/ on the response of baboon alveolar macrophages to migration inhibitory factor
Pulmonary alveolar macrophages (PAM) were obtained by lavage from baboons exposed for 6 mo to 2 ppM NO/sub 2/ for 8 h/d, 5 d/wk, and the response of these cells to autologous migration inhibitory factor (MIF) was determined. The PAM from two of three antigen-stimulated, NO/sub 2/-exposed animals failed to respond to MIF derived from antigen-sensitized autologous lymphocytes. Similarly, PAM from three of the four NO/sup 2/-exposed animals had diminished responsiveness to MIF obtained by phytohemagglutinin stimulation of their own lymphocytes. The altered responsiveness resulted from an effect on the macrophages and not on the lymphocytes used to prepare the MIF, as shown by the normal blastogenic responsiveness of the lymphocytes and the normal activity of the MIF thus produced on guinea pig peritoneal macrophages. These results demonstrate that inhalation of 2 ppM NO/sub 2/ may have important subtle effects on pulmonary cells, which may result in altered immune capabilities within the lung.
- Research Organization:
- Southwest Foundation for Research and Education, San Antonio, TX
- OSTI ID:
- 6539539
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 4:5-6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
IMMUNE REACTIONS
INHIBITION
MACROPHAGES
NITROGEN DIOXIDE
BIOLOGICAL EFFECTS
APES
CHRONIC EXPOSURE
EXPOSURE CHAMBERS
INHALATION
RESPIRATORY TRACT CELLS
ANIMAL CELLS
ANIMALS
CHALCOGENIDES
CONNECTIVE TISSUE CELLS
INTAKE
MAMMALS
NITROGEN COMPOUNDS
NITROGEN OXIDES
OXIDES
OXYGEN COMPOUNDS
PHAGOCYTES
PRIMATES
SOMATIC CELLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)