Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Computed tomography analysis of the canine brain: effects of hemibrain x irradiation

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3576373· OSTI ID:6539140
; ; ; ; ;
Radiation damage induced by megavoltage X irradiation in normal brain tissue can manifest as one of several pathologic processes depending upon the time of brain examination after irradiation. Serial quantitative computed tomography (QCT) analyses were used to study the development of radiation damage in the normal canine brain. Tissue density, volume of low density areas, magnitude and volume of contrast uptake, and ventricular volume were measured following hemibrain irradiation and were correlated with histopathology. Low density areas correlated with edema, demyelination, axonal swelling, and necrosis and appeared 3-4 months after irradiation. Large regions of contrast enhancement appeared 5-6 months after irradiation. Results from this study demonstrated that the pathologic changes induced in the dog brain after single doses of X rays were similar to the changes observed in nonhuman primates and man after exposure to radiation.
Research Organization:
Univ. of California, San Francisco
DOE Contract Number:
AC03-76SF01012
OSTI ID:
6539140
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 99:2; ISSN RAREA
Country of Publication:
United States
Language:
English

Similar Records

Radiation effects in the canine brain evaluated by quantitative computed tomography
Journal Article · Sun Aug 01 00:00:00 EDT 1982 · Radiology; (United States) · OSTI ID:6714052
Radiation effects in the canine brain evaluated by quantitative computed tomography
Journal Article · Sun Aug 01 00:00:00 EDT 1982 · Radiology; (United States) · OSTI ID:6702423
Subacute brain atrophy after radiation therapy for malignant brain tumor
Journal Article · Mon May 15 00:00:00 EDT 1989 · Cancer (Philadelphia); (United States) · OSTI ID:5986824

Related Subjects

550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DELAYED RADIATION EFFECTS
DIAGNOSTIC TECHNIQUES
DOGS
EDEMA
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
IONIZING RADIATIONS
IRRADIATION
MALES
MAMMALS
NECROSIS
NERVOUS SYSTEM
ORGANS
PARTIAL BODY IRRADIATION
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
SYMPTOMS
TOMOGRAPHY
VERTEBRATES
X RADIATION