Effect of hyperthermia upon radiation-induced chromosome loss in mutagen-sensitive Drosophila melanogaster. [/sup 137/Cs]

Journal Article · Wed Apr 01 04:00:00 EST 1981 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575601· OSTI ID:6537781

Mittler, S

Seven mutagen-sensitive mutants representing at least three different defects in the DNA repair pathways were exposed to hyperthermia and ..gamma.. rays in an attempt to understand the mechanisms of hyperthermia sensitization of radiation. The adult males with a Y chromosome marked with y/sup +/ and Bar translocations were used. These males were subjected to 38/sup 0/C for 1 h (13/sup 0/C above optimum) and then to 1200 R of ..gamma.. rays from /sup 137/Cs. These males along with other groups of males exposed only to heat or radiation were mated every 2 days to y/sup 2/w/sup sp/ females to detect the phenotypic loss of X and Y chromosomes and the translocated Bar and y/sup +/. In all the strains that were used, the hyperthermia did enhance the radiation-induced chromosome loss in two or more broods. The hyperthermia, which sensitized the radiation apparently by inhibiting DNA and probably chromosome repair pathways, is not specific for at least three different Drosophila repair pathways.

• Research Organization: Northern Illinois Univ., DeKalb
• OSTI ID: 6537781
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 86:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560154* -- Radiation Effects on Animals-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMALS
ARTHROPODS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY TEMPERATURE
CESIUM 137
CESIUM ISOTOPES
CHROMOSOME LOSSES
CHROMOSOMES
DIPTERA
DNA
DROSOPHILA
ELECTROMAGNETIC RADIATION
FLIES
FRUIT FLIES
GAMMA RADIATION
HETEROCHROMOSOMES
HYPERTHERMIA
INSECTS
INVERTEBRATES
IONIZING RADIATIONS
ISOTOPES
LOSSES
MUTANTS
NUCLEI
NUCLEIC ACIDS
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
SYNERGISM
X CHROMOSOME
Y CHROMOSOME
YEARS LIVING RADIOISOTOPES