Comparison of the inhibition by methylmercury and triethyllead of galactolipid accumulation in rat brain

Journal Article · Sun Nov 30 23:00:00 EST 1980 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(80)90062-6· OSTI ID:6537149

Grundt, I K ^[1]; Neskovic, N M

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1. Univ. of Bergen School of Medicine, Norway

Methylmercury chloride and triethyllead chloride interfere with the myelin deposition in young rats. In order to establish how myelin synthesis and development are affected by these neurotoxins, we have investigated the synthesis of myelin galactolipids using two different systems: (1) slices of cerebellum from 2-week-old rats, (2) enzyme preparations from rat brain. MeHg or Et/sub 3/Pb gave maximum inhibition of the uptake of /sup 35/SO/sub 4/ by sulfatides (63%). The (/sup 3/H)serine uptake by cerebrosides with normal unsubstituted fatty acids was inhibited up to 45% at 70 and 7 ..mu..M of MeHG and Et/sub 3/Pb, respectively, after incubation of the slices for 16 h in an Eagle basal medium at 37/sup 0/C. At the same concentrations the inhibition of (/sup 3/H)serine uptake in cerebrosides with ..cap alpha..-hydroxy fatty acids was about 35%. MeHg inhibited UDPgalactose:ceramide galactosylransferase and phosphoadenosine-5'-phosphosulfate:cerebroside sulfotransferase activities up to 50%, while the inhibition with Et/sub 3/Pb was about 30% at 2.5 mM for the enzymes.

• OSTI ID: 6537149
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 23:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
ANTIGENS
BIOSYNTHESIS
BODY
BRAIN
CARBOHYDRATES
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CEREBELLUM
CEREBROSIDES
CHLORIDES
CHLORINE COMPOUNDS
GLYCOLIPIDS
HALIDES
HALOGEN COMPOUNDS
HYDROXY ACIDS
INHIBITION
LABELLED COMPOUNDS
LEAD COMPOUNDS
LIPIDS
LIPOPROTEINS
MAMMALS
MATERIALS
MERCURY CHLORIDES
MERCURY COMPOUNDS
MERCURY HALIDES
MYELIN
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
ORGANS
PROTEINS
RATS
RODENTS
SACCHARIDES
SENSITIVITY
SERINE
SYNTHESIS
TEL
TOXIC MATERIALS
TOXICITY
TOXINS
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES