Effects of low levels of dietary lead and iron on hepatic RNA, protein, and minerals in young Japanese quail

Journal Article · Sun Apr 01 04:00:00 EST 1984 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(84)90030-6· OSTI ID:6537027

Stone, C L; Fox, M R.S.

Day-old Japanese quail were fed purified diets containing either 0.2 (control), 5.4, or 16.2 ppm lead as the acetate with either 25 (deficient) or 100 ppm (adequate control) iron for 2 weeks. Iron deficiency caused decreases in hemoglobin, iron, and manganese concentrations in the liver, and hepatic RNA synthesis. Iron deficiency also caused increased concentrations of lead, calcium, and molybdenum in the liver. Lead supplements caused increased concentrations of lead in the liver, and with adequate dietary iron, each supplemental lead level caused a slight decrease in the concentration of RNA in the liver. Treatment had no effect on DNA or protein synthesis, body weight, or liver weight in relation to body weight. These low levels of dietary lead did not cause the same adverse metabolic effects observed by others with higher levels of lead; however, iron deficiency increased lead uptake by the liver and affected RNA synthesis. 44 references.

• Research Organization: Food and Drug Administration, Washington, DC
• OSTI ID: 6537027
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 33:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BIRDS
BODY
CALCIUM
CHEMICAL REACTIONS
CHEMISORPTION
CONCENTRATION RATIO
DIGESTIVE SYSTEM
ELEMENTS
FOWL
GLANDS
INGESTION
INTAKE
IRON
LEAD
LIVER
MANGANESE
METALS
MOLYBDENUM
NUCLEIC ACIDS
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RESPONSE MODIFYING FACTORS
RETENTION
RNA
SEPARATION PROCESSES
SORPTION
SYNTHESIS
TRANSITION ELEMENTS
VERTEBRATES
WEIGHT