Effect of dietary selenium level on lead toxicity in the Japanese quail

Journal Article · Thu Jan 01 04:00:00 EST 1976 · Poult. Sci.; (United States)

DOI:https://doi.org/10.3382/ps.0550341· OSTI ID:5742038

Stone, C L; Soares, Jr, J H

In an initial experiment, adult quail hens were given diets supplemented with 0 and 1 p.p.m. selenium and 0, 500 and 1000 p.p.m. lead in a 2 x 3 factorial arrangement. After 32 days of feeding, body weight, liver weight and egg production decreased in birds fed lead while kidney weights increased. Highly significant decreases in red blood cell delta-aminolevulinic acid dehydratase (RCB-ALAD) activity occurred when lead was added to the diet. Selenium supplementation to lead diets of male birds resulted in significantly increased levels of lead in kidney tissue while little or no effects were observed on liver or tibia lead levels. RBC-ALAD activity was significantly reduced with lead supplementation and no effect of selenium addition was observed. Electrophoretic gels of serum from birds fed lead containing diets showed increased protein bands in the transferrin and globulin regions regardless of the presence of 1 p.p.m. selenium. A third study was conducted to determine the effects of supplementing an isolated soy protein diet with 0 and 1 p.p.m. selenium and 0 and 3000 p.p.m. lead. Selenium supplementation improved body weights over controls while lead additions caused reduced egg production and ALAD activity. Lead feeding increased tibia/body weight ratios and lead concentrations in liver, kidney and tibia. No significant interaction between lead and selenium was observed. 26 references, 1 figure, 7 tables.

• Research Organization: Univ. of Maryland, College Park
• OSTI ID: 5742038
• Journal Information: Poult. Sci.; (United States), Journal Name: Poult. Sci.; (United States) Vol. 55:1; ISSN POSCA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIRDS
BODY
CHRONIC EXPOSURE
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
GLANDS
INGESTION
INTAKE
KIDNEYS
LEAD
LIVER
METALS
ORGANS
RESPONSE MODIFYING FACTORS
SELENIUM
SEMIMETALS
SKELETON
TISSUE DISTRIBUTION
TOXICITY
VERTEBRATES