Metallothionein in cadmium-exposed workers

Journal Article · Mon Dec 01 04:00:00 EST 1980 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(80)90076-6· OSTI ID:6536937

Chang, C C ^[1]; Lauwerys, R; Bernard, A; Roels, H; Buchet, J P; Garvey, J S

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1. Syracuse Univ., NY

A radioimmunoassay for human metallothionein (Mt) was utilized to measure urinary Mt in cadmium-exposed and nonexposed workers. Workers in an environment of high concentration had higher Mt levels than those in an environment of lower Cd concentration. Control groups had lower Mt levels than either exposed group. Additional urinary proteins were measured in order to assess functional renal status. Mt. concentration in urine was similar in individuals with and without renal damage. Mt concentration in urine was found to correlate with urinary Cd level, a correlation (r) of 0.94 being obtained between log Cd in urine and log Mt in urine. Additionally, a correlation of 0.82 was obtained between log Cd in blood and log Mt in urine.

• OSTI ID: 6536937
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 23:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BLOOD CHEMISTRY
BODY FLUIDS
CADMIUM
CHEMICAL ANALYSIS
ELEMENTS
ISOTOPE APPLICATIONS
MATERIALS
METALLOPROTEINS
METALLOTHIONEIN
METALS
ORGANIC COMPOUNDS
PERSONNEL
PROTEINS
QUALITATIVE CHEMICAL ANALYSIS
QUANTITY RATIO
RADIOASSAY
RADIOIMMUNOASSAY
TOXICITY
TRACER TECHNIQUES
URINE
WASTES