Metallothionein in plasma and urine of cadmium workers

Journal Article · Tue Jun 01 04:00:00 EDT 1982 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(82)90167-0· OSTI ID:5131827

Nordberg, G F ^[1]; Garvey, J S; Chang, C C

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1. Umea Univ., Sweden

Metallothionein (MT) and ..beta..-2-microglobulin (BM) concentrations were determined in samples of plasma and urine from 31 workers in a Swedish factory manufacturing cadmium batteries. Concentrations of metallothionein in plasma varied from 2 to 11 ng/g and in urine from 2 to 155 ng/g. In workers with urinary BM concentrations above 500 ..mu..g/liter the median value of MT in urine was statistically significantly higher than that in workers with urinary BM concentrations lower than 500 ..mu..g/liter. In individual cases, however, a considerable increase in urinary BM may occur without any increase in urinary MT. The possible significance of increased MT concentrations in plasma, as seen in some of the workers in the present study, in relation to transport of Cd-MT to the renal cortex is pointed out.

• OSTI ID: 5131827
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 28:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

510200* -- Environment
Terrestrial-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CADMIUM
CHRONIC EXPOSURE
CLEARANCE
DISTRIBUTION
ELEMENTS
EXCRETION
GLOBULINS
GLOBULINS-BETA
KIDNEYS
MATERIALS
METALLOPROTEINS
METALLOTHIONEIN
METALS
ORGANIC COMPOUNDS
ORGANS
PERSONNEL
PROTEINS
QUANTITY RATIO
RENAL CLEARANCE
TISSUE DISTRIBUTION
URINE
WASTES