Biological effects summary report: acridine

Technical Report · Tue May 01 04:00:00 EDT 1984

OSTI ID:6536759

Keimig, D; Muff, S

A comprehensive review of acridine was conducted to assess the potential health effects of this nitorgen heterocyclic compound and to evaluate the need for recommending an interim occupational exposure limit to protect the health of exposed workers. Acridine, formed as a trace pollutant during incomplete combustion of nitrogen-containing materials, has been identified as a constituent of coal tar, coal distillates, and shale oil. Concentrations of acridine in urban and industrial settings were generally one to two orders of magnitude lower than the levels recorded for benzo(a)pyrene. In humnas, acridine is a known irritant of the skin and mocous membranes, but systemic effects attributed to acridine have actually involved exposure to either an acridine derivative or to coal-tar pitch and it is not clear whether these effects can be attributed solely, or even partly, to acridine exposures. At this time, we do not recommend that a standard be set specific to acridine, since available data on biological effects are limited, and since possible effects due to interactions of acridine and the myriad of polynuclear aromatic compounds present during typical exposures have not been assessed. 98 references, 1 figure, 8 tables.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6536759
• Report Number(s): BNL-51741; ON: DE84017243
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRIDINES
AROMATICS
AZAARENES
AZINES
BIOLOGICAL EFFECTS
COMBUSTION PRODUCTS
DATA
DATA COMPILATION
DOSE LIMITS
HETEROCYCLIC COMPOUNDS
INFORMATION
METABOLISM
NUMERICAL DATA
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIDINES
SAFETY STANDARDS
STANDARDS
TOXICITY