Simultaneous effects of erythropoietin and colony-stimulating factor on bone-marrow cells

Journal Article · Fri Nov 18 04:00:00 EST 1977 · Science; (United States)

DOI:https://doi.org/10.1126/science.302986· OSTI ID:6531789

Van Zant, G; Goldwasser, E

Erythropoietin or colony-stimulating factor, or both, were added to rat or mouse marrow cell cultures, and the responses to each inducer were measured. Colony-stimulating factor caused the suppression of erythropoietin-stimulated hemoglobin synthesis, and erythropoietin caused the suppression of the granulocytemacrophage colony formation that is dependent on colony-stimulating factor. The extent of suppression by each inducer was dose-dependent. Marrow cells from plethoric rats were more sensitive to suppression of erythropoietin action by colony-stimulating factor than were normal marrow cells. These findings suggest that either (1) the receptors for erythropoietin and for colony-stimulating factor have overlapping specificities and that the ''wrong'' inducer may bind without having an inductive effect, or (2) the target cells for erythropoietin and colony-stimulating factor are very closely related or are the same.

• Research Organization: Univ. of Chicago, IL
• OSTI ID: 6531789
• Journal Information: Science; (United States), Journal Name: Science; (United States) Vol. 198; ISSN SCIEA
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
550300 -- Cytology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BONE MARROW CELLS
CARBOXYLIC ACIDS
CELL CULTURES
CFU
CONNECTIVE TISSUE CELLS
ERYTHROPOIETIN
GLOBIN
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
MAMMALS
MICE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
RATS
RODENTS
SOMATIC CELLS
SYNTHESIS
VERTEBRATES